Taiwanese Journal of Obstetrics and Gynecology
Volume 46, Issue 2 , Pages 135-145 , June 2007

The Interactions Between GPR30 and the Major Biomarkers in Infiltrating Ductal Carcinoma of the Breast in an Asian Population

  • Wen-Hung Kuo

      Affiliations

    • Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
    • Angiogenesis Research Center, National Taiwan University, Taipei, Taiwan
    • ,
  • Li-Yun Chang

      Affiliations

    • Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Daisy Li-Yu Liu

      Affiliations

    • Biometrics Division, Department of Agronomy, National Taiwan University, Taipei, Taiwan
    • ,
  • Hsiao-Lin Hwa

      Affiliations

    • Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Jen-Jen Lin

      Affiliations

    • Department of Applied Statistics and Information Science, Ming Chuan University, Taipei, Taiwan
    • ,
  • Po-Huang Lee

      Affiliations

    • Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
    • Angiogenesis Research Center, National Taiwan University, Taipei, Taiwan
    • ,
  • Chiung-Nien Chen

      Affiliations

    • Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
    • Angiogenesis Research Center, National Taiwan University, Taipei, Taiwan
    • Division of Mechanics, Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan
    • ,
  • Huang-Chun Lien

      Affiliations

    • Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Ray-Hwang Yuan

      Affiliations

    • Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Chia-Tung Shun

      Affiliations

    • Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • King-Jen Chang

      Affiliations

    • Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
    • Angiogenesis Research Center, National Taiwan University, Taipei, Taiwan
    • ,
  • Fon-Jou Hsieh

      Affiliations

    • Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan
    • Graduate Institute of Clinical Research, National Taiwan University Hospital, Taipei, Taiwan
    • Department of Life Science, National Taiwan University, Taipei, Taiwan
    • Center of Systems Biology and Bioinformatics, National Taiwan University, Taipei, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Fon-Jou Hsieh, Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University Hospital, 7, Chung-Shan South Road, Taipei 100, Taiwan

,Accepted 12 March 2007.

References 

  1. Chen CJ , You SL , Lin LH , Hsu WL , Yang YW . Cancer epidemiology and control in Taiwan: a brief review . Jpn J Clin Oncol . 2002;32(Suppl 1):S66–S81
  2. Pike MC , Spicer DV , Dahmoush L , Press MF . Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk . Epidemiol Rev . 1993;15:17–35
  3. Carmeci C , Thompson DA , Ring HZ , Francke U , Weigel RJ . Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer . Genomics . 1997;45:607–617
  4. Kakinuma N , Sato M , Yamada T , et al.   Cloning of novel LERGU mRNAs in GPR30 3' untranslated region and detection of 2 bp-deletion polymorphism in gastric cancer . Cancer Sci . 2005;96:191–196
  5. Takada Y , Kato C , Kondo S , Korenaga R , Ando J . Cloning of cDNAs encoding G protein-coupled receptor expressed in human endothelial cells exposed to fluid shear stress . Biochem Biophys Res Commun . 1997;240:737–741
  6. Filardo EJ , Quinn JA , Frackelton AR , Bland KI . Estrogen action via the G-protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis . Mol Endocrinol . 2002;16:70–84
  7. Maggiolini M , Vivacqua A , Fasanella G , et al.   The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17b-estradiol and phytoestrogens in breast cancer cells . J Biol Chem . 2004;279:27008–27016
  8. Manavathi B , Kumar R . Steering estrogen signals from the plasma membrane to the nucleus: two sides of the coin . J Cell Physiol . 2006;207:594–604
  9. Revankar CM , Cimino DF , Sklar LA , Arterburn JB , Prossnitz ER . A transmembrane intracellular estrogen receptor mediates rapid cell signaling . Science . 2005;307:1625–1630
  10. Pedram A , Razandi M , Levin ER . Nature of functional estrogen receptors at the plasma membrane . Mol Endocrinol . 2006;20:1996–2009
  11. Bookout AL , Cummins CL , Kramer MF , Pesola JM , Mangelsdorf DJ . High-throughput real-time quantitative reverse transcription PCR . In:  Ausubel FM ,  Brent R ,  Kingston RE ,  Moore DDJ editor. Current Protocols in Molecular Biology . New Jersey: John Wiley and Sons; 2006;p. 15.8.1–15.828
  12. Kuehl RO . Statistical Principles of Research Design and Analysis . 2nd edition. Belmont (CA): Duxbury Press; 2000;
  13. Chambers J , Cleveland W , Kleiner B , Tukey P . Graphical Methods for Data Analysis . Belmont (CA): Wadsworth; 1983;
  14. Filardo EJ , Graeber CT , Quinn JA , et al.   Distribution of GPR30, a seven membrane-spanning estrogen receptor, in primary breast cancer and its association with clinicopatho-logic determinants of tumor progression . Clin Cancer Res . 2006;12:6359–6366
  15. Hudelist G , Czerwenka K , Kubista E , Marton E , Pischinger K , Singer CF . Expression of sex steroid receptors and their co-factors in normal and malignant breast tissue: AIB1 is a carcinoma-specific co-activator . Breast Cancer Res Treat . 2003;78:193–204
  16. Lapidus RG , Nass SJ , Davidson NE . The loss of estrogen and progesterone receptor gene expression in human breast cancer . J Mammary Gland Biol Neoplasia . 1998;3:85–94
  17. Leu YW , Yan PS , Fan M , et al.   Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer . Cancer Res . 2004;64:8184–8192
  18. Dubey S , Siegfried JM , Traynor AM . Non-small-cell lung cancer and breast carcinoma: chemotherapy and beyond . Lancet Oncol . 2006;7:416–424
  19. Daniel JM . Effects of oestrogen on cognition: what have we learned from basic research? . J Neuroendocrinol . 2006;18:787–795
  20. Dhandapani KM , Brann DW . Role of astrocytes in estrogen-mediated neuroprotection . Exp Gerontol . 2007;42:70–75
  21. Thakur MK , Sharma APK . Aging of brain: role of estrogen . Neurochem Res . 2006;31:1389–1398

PII: S1028-4559(07)60007-2

doi: 10.1016/S1028-4559(07)60007-2

Taiwanese Journal of Obstetrics and Gynecology
Volume 46, Issue 2 , Pages 135-145 , June 2007

Article Tools