Taiwanese Journal of Obstetrics and Gynecology
Volume 46, Issue 3 , Pages 230-235 , September 2007

Total hCG Versus Free β-hCG Combined with Alpha-fetoprotein for Down Syndrome Screening in Taiwan

  • Tsang-Tang Hsieh

      Affiliations

    • Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Taipei, Taiwan
    • ,
  • Jenn-Jeih Hsu

      Affiliations

    • Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Taipei, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Jenn-Jeih Hsu, Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Chang Gung University, 199, Tung-Hwa North Road, Taipei, Taiwan
    • ,
  • Po-Jen Cheng

      Affiliations

    • Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou, Taiwan
    • ,
  • Chien-Nan Lee

      Affiliations

    • Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan
    • ,
  • Hei-Jen Jou

      Affiliations

    • Department of Obstetrics and Gynecology, Taiwan Adventist Hospital, Taipei, Taiwan
    • ,
  • Chih-Ping Chen

      Affiliations

    • Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan

,Accepted 26 September 2006.

References 

  1. Hsu JJ , Hsieh TT , Hsieh FJ . Down syndrome screening in an Asian population using alpha-fetoprotein and free beta-hCG: a report of the Taiwan Down Syndrome Screening Group . Obstet Gynecol . 1996;87:943–947
  2. Palomaki GE , Knight GJ , McCarthy JE , Haddow JE , Donhowe JM . Maternal serum screening for Down syndrome in the United States: a 1995 survey . Am J Obstet Gynecol . 1996;176:1046–1051
  3. Macintosh M , Ellis A , Cuckle H , Seth J . Variation in biochemical screening for Down's syndrome in the United Kingdom . Br J Obstet Gynaecol . 1998;105:465–467
  4. Macri JN , Kasturi RV , Krantz DA , et al.   Maternal serum Down syndrome screening: free β-protein is a more effective marker than human chorionic gonadotropin . Am J Obstet Gynecol . 1990;163:1248–1253
  5. Spencer K . Evaluation of an assay of the free β-subunit of choriogonadotropin and its potential value in screening for Down's syndrome . Clin Chem . 1991;37:809–814
  6. Spencer K , Coombes EJ , Mallard AS , Ward AM . Free beta human choriogonadotropin in Down's syndrome screening: a multicentre study of its role compared with other biochemical markers . Ann Clin Biochem . 1992;29:506–518
  7. Wald N , Densem J , Stone R , Cheng R . The use of free β-hCG in antenatal screening for Down's syndrome . Br J Obstet Gynaecol . 1993;100:550–557
  8. Hsu JJ , Hsieh TT , Soong YK , Spencer K . Comparison of Down's syndrome screening strategies in Asians combining serum free beta-hCG and alpha-fetoprotein with maternal age . Prenat Diagn . 1997;17:707–716
  9. Wald NJ , Densem JW , Smith D , Klee GG . Four-marker serum screening for Down's syndrome . Prenat Diagn . 1994;14:707–716
  10. Knight GJ , Palomaki GE , Neveux LM , Fodor KK , Haddow JE . hCG and the free β-subunit as screening tests for Down syndrome . Prenat Diagn . 1998;18:235–245
  11. Wenstrom KD , Owen J , Chu DC , Boots L . Free β-hCG sub-unit versus intact hCG in Down syndrome screening . Obstet Gynecol . 1997;90:370–374
  12. Spencer K . Is the measurement of unconjugated oestriol of value in screening for Down's syndrome . In:  Grudzinskas JG ,  Chard T ,  Chapman M ,  Cuckle H editor. Screening for Down's Syndrome . Cambridge: Cambridge University Press; 1994;p. 141–161
  13. Hsu JJ , Chiu TH , Chen KC , Liou JD , Hsieh TT , Soong YK . Maternal serum alpha-fetoprotein levels between 13 and 24 weeks' gestation . Chang Gung Med J . 1994;17:309–315
  14. Hsu JJ , Hsieh TT , Lo LM , Soong YK . Midtrimester human chorionic gonadotropin levels: Normal references values in Chinese pregnant women . Chang Gung Med J . 1995;18:240–247
  15. Hsu JJ , Hsieh TT , Hung TH , Chiang CH . Midtrimester maternal serum free beta-human chorionic gonadotropin levels: normal reference values for Taiwanese women . Chang Gung Med J . 1998;21:277–282
  16. Hsu JJ , Hsieh TT , Soong YK . Influence of maternal age and weight on second-trimester serum alpha-fetoprotein, total and free beta human chorionic gonadotropin levels . Chang Gung Med J . 1997;20:181–186
  17. Cuckle HS , Wald NJ , Thompson SG . Estimating a woman's risk of having a pregnancy associated with Down's syndrome using her age and serum alpha-fetoprotein level . Br J Obstet Gynaecol . 1987;94:387–402
  18. Reynolds TM , Penney MD . The mathematical basis of multivariate risk screening: with special reference to screening for Down's syndrome associated pregnancy . Ann Clin Biochem . 1990;27:452–458
  19. Bogart MH , Pandian MR , Jones OW . Abnormal maternal serum chorionic gonadotropin levels in pregnancies with fetal chromosome abnormalities . Prenat Diagn . 1987;7:623–630
  20. Canick JA , Knight GJ . Multiple-marker screening for fetal Down syndrome . Contemp Ob Gyn . 1992;4:3–12
  21. Lam YH, Ghosh A, Tang MH, Tang LC, Lee CP, Sin SY, et al. Second-trimester maternal serum alpha-fetoprotein and human chorionic gonadotrophin screening for Down's syndrome in Hong Kong . Prenat Diagn . 1998;18:585–589
  22. Eldar-Geva T , Hochberg A , deGroot N , Weinstein D . High maternal serum chorionic gonadotropin level in Down's syndrome pregnancies is caused by elevation of both sub-units messenger ribonucleic acid level in trophoblasts . J Clin Endocrinol Metab . 1995;80:3528–3531
  23. Ryall RG , Staples AJ , Robertson EF , Pollard AC . Improved performance in a prenatal screening programme for Down's syndrome incorporating serum-free hCG subunit analyses . Prenat Diagn . 1992;12:251–261
  24. Macri JN , Spencer K , Garver K , et al.   Maternal serum free beta hCG screening: results of studies including 480 cases of Down syndrome . Prenat Diagn . 1994;14:97–103
  25. Cuckle HS , Wald NJ , Lindenbaum RH . Maternal serum alpha-fetoprotein measurement: a screening test for Down syndrome . Lancet . 1984;1:926–929
  26. Spencer K , Carpenter P . Screening for Down's syndrome using serum α-fetoprotein: a retrospective study indicating caution . Br Med J (Clin Res Ed) . 1985;290:1940–1943
  27. Cuckle HS , Ellis AR , Seth J . Provision of screening for Down's syndrome . BMJ . 1995;311:512–514
  28. Spencer K , Macri JN , Aitken DA , Connor JM . Free β-hCG as first-trimester marker for fetal trisomy . Lancet . 1992;339:1480–1481
  29. Wald NJ , Kennard A , Hackshaw AK . First trimester serum screening for Down's syndrome . Prenat Diagn . 1995;15:1227–1240

PII: S1028-4559(08)60025-X

doi: 10.1016/S1028-4559(08)60025-X

Taiwanese Journal of Obstetrics and Gynecology
Volume 46, Issue 3 , Pages 230-235 , September 2007

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