Taiwanese Journal of Obstetrics and Gynecology
Volume 46, Issue 3 , Pages 264-266, September 2007

Advanced Cervical Squamous Cell Carcinoma with Skin Metastasis

  • Chia-Hui Chen
    • ,
  • Kuan-Chong Chao
    • ,
  • Peng-Hui Wang

      Affiliations

    • Corresponding Author InformationCorrespondence to: Dr Peng-Hui Wang, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, 201 Shi-Pai Road, Section 2, Taipei 112, Taiwan

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan

Accepted 22 November 2006.

Article Outline

Summary 

Objective

Although cervical cancer is a very common gynecologic malignancy, skin metastasis presenting as an initial sign of recurrent or persistent disease is extremely rare.

Case Report

A 72-year-old woman was diagnosed with squamous cell carcinoma of the cervix (FIGO stage, IIB), which was treated with concurrent chemoradiation. After treatment, she was followed up regularly, without evidence of disease. One year later, many erythematous lesions were noted on the extremities, trunk, and scalp. Some of skin lesions grew rapidly. Excision biopsy was performed and showed metastatic carcinoma, favoring a squamous cell type. The patient then underwent a series of imaging examinations, including magnetic resonance imaging of the pelvis and computed tomography of the chest, and a whole body bone scan showed disseminated diseases involving the lung and bone. Palliative chemotherapy was prescribed, and the skin lesions responded relatively well, but disease involving the vital organs still progressed during treatment. The patient died of the disease 6 months after the appearance of the skin lesion.

Conclusion

This report supports the concept that skin metastasis is a late manifestation and an ominous sign for cervical cancer patients, and also indicates the uncontrolled or widespread metastasis of the disease.

Key Words:  cervical cancer , skin metastasis

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References 

  1. Wang PH , Lee WL , Lee YR , et al.   Enhanced expression of α2,6-sialyltransferase ST6Gal I in cervical squamous cell carcinoma . Gynecol Oncol . 2003;89:395–401
  2. Carlson V , Delclos L , Fletcher GH . Distant metastases in squamous-cell carcinoma of the uterine cervix . Radiology . 1967;88:961–966
  3. Brady LW , O'Neill EA , Farber SH . Unusual sites of metas-tases . Semin Oncol . 1977;4:59–64
  4. Tharakaram S , Rajendran SS , Premalatha S , Yesudian P , Zahara A . Cutaneous metastasis from carcinoma cervix . Int J Dermatol . 1985;24:598–599
  5. Franciolini G, Momoli G, Minelli L, Mutolo F, Franchini MA, Chiodini S, et al. Cutaneous metastases from carcinoma of the cervix . Tumori . 1990;76:410–412
  6. Hayes AG , Berry AD . Cutaneous metastasis from squa-mous cell carcinoma of the cervix . J Am Acad Dermatol . 1992;26:846–850
  7. Imachi M , Tsukamoto N , Kinoshita S , Nakano H . Skin metastasis from carcinoma of the uterine cervix . Gynecol Oncol . 1993;48:349–354
  8. Fogaca MF , Fedorciw BJ , Tahan SR , Johnson R , Federman M . Cutaneous metastasis of neuroendocrine carcinoma of uterine origin . J Cutan Pathol . 1993;20:455–458
  9. Shimizu I , Hayashi S , Uehara M , Nakayama S . Cutaneous metastases to the scalp from carcinoma of the uterine cervix . Arch Dermatol . 1983;119:275–276
  10. Rath GK , Misra BK , Jayalakshmi S . Scalp metastasis of a uterine cervix carcinoma . Obstet Gynaecol Today . 2000;8:488–489
  11. Maheshwari GK , Baboo HA , Ashwathkumar R , Dave KS , Wadhwa MK . Scalp metastasis from squamous cell carcinoma of the cervix . Int J Gynecol Cancer . 2001;11:244–246
  12. Park JY , Lee HS , Cho KH . Cutaneous metastasis to the scalp from squamous cell carcinoma of the cervix . Clin Exp Dermatol . 2003;28:28–30
  13. Tsai HW , Yuan CC , Wang PH . Umbilicus as the only site of metastasis in recurrent ovarian cancer . J Chin Med Assoc . 2006;69:233–235
  14. Wang PH , Yuan CC , Lin G , Ng HT , Chao HT . Risk factors contributing to early occurrence of port site metastases of laparoscopic surgery for malignancy . Gynecol Oncol . 1999;72:38–44

PII: S1028-4559(08)60031-5

doi:10.1016/S1028-4559(08)60031-5

Taiwanese Journal of Obstetrics and Gynecology
Volume 46, Issue 3 , Pages 264-266, September 2007

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