The Application of Three-dimensional Ultrasonography in the Prenatal Diagnosis of Arthrogryposis

Summary 

Objective

To present the application of three-dimensional (3D) ultrasonography in the early prenatal diagnosis of fetal arthrogryposis.

Case Report

A 26-year-old multipara had a fetus with anomalies of the limbs as shown by conventional ultrasonography at 18 weeks of gestation. A follow-up 3D ultrasonogram at the same gestational age was consistent with the diagnosis of arthrogryposis. Based on an abnormal chromosome 18p on the fetal karyotype, termination of the pregnancy was performed at 22 weeks' gestation. The outward appearance of the fetus coincided with the prenatal sonographic findings of arthrogryposis.

Conclusion

As an advanced and sophisticated technology, 3D ultrasonography can serve as a useful technique for the early diagnosis of fetal anomalies, including arthrogryposis. The earlier the diagnosis is established, the earlier the appropriate management can be initiated, including counseling, additional work-up and timely termination of pregnancy, if indicated.

Key Words:  arthrogryposis , prenatal diagnosis , three-dimensional ultrasonography

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