Taiwanese Journal of Obstetrics and Gynecology
Volume 47, Issue 2 , Pages 168-174 , June 2008

Increased Progesterone/Estradiol Ratio on the Day of hCG Administration Adversely Affects Success of In Vitro Fertilization–Embryo Transfer in Patients Stimulated with Gonadotropin-releasing Hormone Agonist and Recombinant Follicle-stimulating Hormone

  • Yu-Che Ou

      Affiliations

    • Chang Gung Memorial Hospital—Kaohsiung Medical Center, Chang Cung University College of Medicine, Kaohsiung, Taiwan
    • ,
  • Kuo-Chung Lan

      Affiliations

    • Chang Gung Memorial Hospital—Kaohsiung Medical Center, Chang Cung University College of Medicine, Kaohsiung, Taiwan
    • Department of Obstetrics and Gynecology, ChangGung University School of Medicine, Taoyuan, Taiwan
    • ,
  • Shiuh-Young Chang

      Affiliations

    • Chang Gung Memorial Hospital—Kaohsiung Medical Center, Chang Cung University College of Medicine, Kaohsiung, Taiwan
    • Department of Obstetrics and Gynecology, ChangGung University School of Medicine, Taoyuan, Taiwan
    • ,
  • Fu-Tsai Kung

      Affiliations

    • Chang Gung Memorial Hospital—Kaohsiung Medical Center, Chang Cung University College of Medicine, Kaohsiung, Taiwan
    • Department of Obstetrics and Gynecology, ChangGung University School of Medicine, Taoyuan, Taiwan
    • ,
  • Fu-Jen Huang

      Affiliations

    • Chang Gung Memorial Hospital—Kaohsiung Medical Center, Chang Cung University College of Medicine, Kaohsiung, Taiwan
    • Department of Obstetrics and Gynecology, ChangGung University School of Medicine, Taoyuan, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Fu-Jen Huang, Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, 123 Ta-Pei Road, Niao Sung Hsiang, Kaohsiung, Taiwan

,Accepted 20 September 2007.

References 

  1. Hofmann GE , Khoury J , Michener C . Elevated serum progesterone-to-estradiol ratio during gonadotropin stimulation for intrauterine insemination or in vitro fertilization is not associated with diminished ovarian reserve . Fertil Steril . 2002;78:47–50
  2. Younis JS , Matilsky M , Radin O , Ben-Ami M . Increased progesterone/estradiol ratio in the late follicular phase could be related to low ovarian reserve in in vitro fertilization-embryo transfer cycles with a long gonadotropinreleasing hormone agonist . Fertil Steril . 2001;76:294–299
  3. Fanchin R , Righini C , Olivennes F , Ferreira AL , de Ziegler D , Frydman R . Consequences of premature progesterone elevation on the outcome of in vitro fertilization: insights into a controversy . Fertil Steril . 1997;68:799–805
  4. Ubaldi F , Camus M , Smitz J , Bennink HC , Van Steirteghem A , Devroey P . Premature luteinization in in vitro fertilization cycles using gonadotropin-releasing hormone agonist (GnRH-a) and recombinant follicle-stimulating hormone (FSH) and GnRH-a and urinary FSH . Fertil Steril . 1996;66:275–280
  5. Fanchin R , de Ziegler D , Taieb J , Hazout A , Frydman R . Premature elevation of plasma progesterone alters pregnancy rates of in vitro fertilization and embryo transfer . Fertil Steril . 1993;59:1090–1094
  6. Edelstein MC , Seltman HJ , Cox BJ , Robinson SM , Shaw RA , Muasher SJ . Progesterone levels on the day of human chorionic gonadotropin administration in cycles with gonadotropin-releasing hormone agonist suppression are not predictive of pregnancy outcome . Fertil Steril . 1990;54:853–857
  7. Silverberg KM , Burns WN , Olive DL , Riehl RM , Schenken RS . Serum progesterone levels predict success of in vitro fertilization-embryo transfer in patients stimulated with leuprolide acetate and human menopausal gonadotropins . J Clin Endocrinol Metab . 1991;73:797–803
  8. Check JH , Chase JS , Nowroozi K , Dietterich CJ . Premature luteinization: treatment and incidence in natural cycles . Hum Reprod . 1991;6:190–193
  9. Hofmann GE, Bentzien F, Bergh PA, Garrisi GJ, Williams MC, Guzman I, et al. Premature luteinization in controlled ovarian hyperstimulation has no adverse effect on oocyte and embryo quality . Fertil Steril . 1993;60:675–679
  10. Givens CR , Schriock ED , Dandekar PV , Martin MC . Elevated serum progesterone levels on the day of human chorionic gonadotropin administration do not predict outcome in assisted reproduction cycles . Fertil Steril . 1994;62:1011–1017
  11. Harada T , Yoshida S , Katagiri C , Takao N , Ikenari T , Toda T , et al.   Reduced implantation rate associated with a subtle rise in serum progesterone concentration during the follicular phase of cycles stimulated with a combination of a gonadotrophin-releasing hormone agonist and gonadotrophin . Hum Reprod . 1995;10:1060–1064
  12. Younis JS , Simon A , Laufer N . Endometrial preparation: lessons from oocyte donation . Fertil Steril . 1996;66:873–884
  13. Copperman AB , Horowitz GM , Kaplan P , Scott RT , Navot D , Hofmann GE . Relationship between circulating human chorionic gonadotropin levels and premature luteinization in cycles of controlled ovarian hyperstimulation . Fertil Steril . 1995;63:1267–1271
  14. Adonakis G , Deshpande N , Yates RWS , Fleming R . Luteinizing hormone increases estradiol secretion but has no effect on progesterone concentrations in the late follicular phase of in vitro fertilization cycles in women treated with gonadotropin-releasing hormone agonist and folliclestimulating hormone . Fertil Steril . 1998;69:450–453
  15. Huang FJ , Chang SY , Tsai MY , Kung FT , Wu JF , Chang HW . Determination of the efficiency of controlled ovarian hyperstimulation in the gonadotropin-releasing hormone agonistsuppression cycle using the initial follicle count during gonadotropin stimulation . J Assist Reprod Genet . 2001;18:91–96
  16. Tsai MY, Huang FJ, Kung FT, Lin YC, Chang SY, Wu JF, et al. Influence of polyvinylpyrrolidone on the outcome of intracytoplasmic sperm injection . J Reprod Med . 2000;45:112–120
  17. Huang FJ, Huang HW, Lan KC, Kung FT, Lin YC, Chang HW, et al. The maturity of human cumulus-free oocytes is positively related to blastocyst development and viability . J Assist Reprod Genet . 2002;19:555–560
  18. Veeck LL . Preembryo grading . In:  Veeck LL editors. Atlas of the Human Oocyte and Early Conceptus . Volume 2: Baltimore, MD: Williams and Wilkins; 1991;
  19. Gardner DK , Lane M , Stevens J , Schlenker T , Schoolcraft WB . Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer . Fertil Steril . 2000;73:1155–1158
  20. Lan KC , Huang FJ , Lin YC , et al.   The predictive value of using a combined Z-score and day 3 embryo morphology score in the assessment of embryo survival on day 5 . Hum Reprod . 2003;18:1299–1306
  21. Huang FJ , Lan KC , Kung FT , et al.   Human cumulus-free oocyte maturational profile and in vitro developmental potential after stimulation with recombinant versus urinary FSH . Hum Reprod . 2004;19:306–315
  22. Schoolcraft W , Sinton E , Schlenker T , Huynh D , Hamilton F , Meldrum DR . Lower pregnancy rate with premature luteinization during pituitary suppression with leuprolide acetate . Fertil Steril . 1991;55:563–566
  23. Özçakir HT , Levi R , Tavmergen E , Göker EN . Premature luteinization defined as progesterone estradiol ratio > 1 on hCG administration day seems to adversely affect clinical outcome in long gonadotropin-releasing hormone agonist cycles . J Obstet Gynaecol Res . 2004;30:100–104
  24. Cedars MI , Surey E , Hamilton F , Lapolt P , Meldrum DR . Leuprolide acetate lowers circulating bioactive luteinizing hormone and testosterone concentrations during ovarian stimulation for oocyte retrieval . Fertil Steril . 1990;53:627–631
  25. Ron-El R . Improved pregnancy rate in IVF/ET by combined long-acting GnRH analogue and gonadotropins . In:  Vickery BH ,  Lunenfeld B editor. GnRH Analogues in Reproduction and Gynecology . Volume II: Dordrecht/Boston/London: Kluwer Academic Publishers; 1990;p. 167–171
  26. Penzias AS , Shamma FN , Gutmann JN , Jones EE , DeCherney AH , Lavy G . Nafarelin versus leuprolide in ovulation induction for in vitro fertilization: a randomized clinical trial . Obstet Gynecol . 1992;79:739–742
  27. Stokman PGW , de Leeuw R , van den Wijngaard HAGW , Kloosterboer HJ , Vemer HM , Sanders ALM . Human chorionic gonadotropin in commercial human menopausal gonadotropin preparations . Fertil Steril . 1993;60:175–178
  28. Mannaerts B, de Leeuw R, Geelen J, Van Ravestein A, Van Wezenbeek P, Schuurs A, et al. Comparative in vitro and in vivo studies on the biological characteristics of recombinant human follicle-stimulating hormone . Endocrinology . 1991;129:2623–2630
  29. Shaw RW , Ndukwe G , Imoedemhe DA , Bernard AG , Burford G . Twin pregnancy after pituitary desensitisation with LHRH agonist and pure FSH . Lancet . 1985;326:506–507
  30. Gonzalez-Robayana U , Falender AE , Ochsner S , Firestone GL , Richards JS . Follicle-stimulating hormone (FSH) stimulates phosphorylation and activation of protein kinase B (PKB/Akt) and serum and glucocorticoid-induced kinase (Sgk): evidence for A kinase-independent signaling by FSH in granulosa cells . Mol Endocrinol . 2000;14:1283–1300
  31. Richards JS . New signaling pathways for hormones and cyclic adenosine 3→,5→-monophosphate action in endocrine cells . Mol Endocrinol . 2001;15:209–218
  32. Richards JS , Russell DL , Ochsner S , et al.   Novel signaling pathways that control ovarian follicular development, ovulation and luteinization . Recent Prog Horm Res . 2002;57:195–220
  33. Filicori M, Cognigni GE, Pocognoli P, Tabarelli C, Spettoli D, Taraborrelli S, et al. Modulation of folliculogenesis and steroidogenesis in women by graded menotrophin administration . Hum Reprod . 2002;17:2009–2015

PII: S1028-4559(08)60075-3

doi: 10.1016/S1028-4559(08)60075-3

Taiwanese Journal of Obstetrics and Gynecology
Volume 47, Issue 2 , Pages 168-174 , June 2008

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