Taiwanese Journal of Obstetrics and Gynecology
Volume 47, Issue 4 , Pages 422-430 , December 2008

Genetic Network Analysis of Human CD34+ Hematopoietic Stem/Precursor Cells

  • Shing-Jyh Chang

      Affiliations

    • Department of Obstetrics and Gynecology, Mackay Memorial Hospital, HsinChu, Taiwan
    • National Tsing Hua University, HsinChu, Taiwan
  • ,
  • Tse-Sung Huang

      Affiliations

    • Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan
  • ,
  • Kung-Liahng Wang

      Affiliations

    • Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
    • National Taipei College of Nursing, Taipei, Taiwan
    • Mackay Medicine, Nursing and Management College, Taipei, Taiwan
  • ,
  • Tao-Yeuan Wang

      Affiliations

    • Department of Pathology, Mackay Memorial Hospital, Taipei, Taiwan
  • ,
  • Yuh-Cheng Yang

      Affiliations

    • Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
  • ,
  • Margaret Dah-Tsyr Chang

      Affiliations

    • National Tsing Hua University, HsinChu, Taiwan
  • ,
  • Yu-Hsuan Wu

      Affiliations

    • Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan
  • ,
  • Hsei-Wei Wang

      Affiliations

    • Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan
    • Institute of Clinical Medicine, Taipei City Hospital, Taipei, Taiwan
    • VGH-YM Genome Center, National Yang-Ming, Taipei City Hospital, Taipei, Taiwan
    • University, and Department of Education and Research, Taipei City Hospital, Taipei, Taiwan
    • Corresponding Author InformationCorrespondence to Dr Hsei-Wei Wang, Institute of Microbiology and Immunology, National Yang-Ming University, 155, Section 2, Li-Nong Street, Taipei, Taiwan

,Accepted 7 March 2008.

References 

  1. Brunstein CG , Baker KS , Wagner JE . Umbilical cord blood transplantation for myeloid malignancies . Curr Opin Hematol . 2007;14:162–169
  2. Ng YY, van Kessel B, Lokhorst HM, Baert MR, van den Burg CM, Bloem AC, et al. Gene-expression profiling of CD34+ cells from various hematopoietic stem-cell sources reveals functional differences in stem-cell activity . J Leukoc Biol . 2004;75:314–323
  3. Oswald J , Steudel C , Salchert K , et al.   Gene-expression profiling of CD34+ hematopoietic cells expanded in a collagen I matrix . Stem Cells . 2006;24:494–500
  4. Salven P , Mustjoki S , Alitalo R , Alitalo K , Rafii S . VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells . Blood . 2003;101:168–172
  5. Peichev M , Naiyer AJ , Pereira D , et al.   Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors . Blood . 2000;95:952–958
  6. Ivanova NB , Dimos JT , Schaniel C , Hackney JA , Moore KA , Lemischka IR . A stem cell molecular signature . Science . 2002;298:601–604
  7. Loges S , Fehse B , Brockmann MA , et al.   Identification of the adult human hemangioblast . Stem Cells Dev . 2004;13:229–242
  8. Jaatinen T , Hemmoranta H , Hautaniemi S , et al.   Global gene expression profile of human cord blood-derived CD133+ cells . Stem Cells . 2006;24:631–641
  9. Phillips RL , Ernst RE , Brunk B , et al.   The genetic program of hematopoietic stem cells . Science . 2000;288:1635–1640
  10. Park IK , He Y , Lin F , et al.   Differential gene expression profiling of adult murine hematopoietic stem cells . Blood . 2002;99:488–498
  11. Ramalho-Santos M , Yoon S , Matsuzaki Y , Mulligan RC , Melton DA . “Stemness”: transcriptional profiling of embryonic and adult stem cells . Science . 2002;298:597–600
  12. Bruno L , Hoffmann R , McBlane F , et al.   Molecular signatures of self-renewal, differentiation, and lineage choice in multipotential hemopoietic progenitor cells in vitro . Mol Cell Biol . 2004;24:741–756
  13. Georgantas RW , Tanadve V , Malehorn M , et al.   Microarray and serial analysis of gene expression analyses identify known and novel transcripts overexpressed in hematopoietic stem cells . Cancer Res . 2004;64:4434–4441
  14. Featherstone DE , Broadie K . Wrestling with pleiotropy: genomic and topological analysis of the yeast gene expression network . Bioessays . 2002;24:267–274
  15. Jen CH , Manfield IW , Michalopoulos I , et al.   The Arabidopsis co-expression tool (ACT): a WWW-based tool and database for microarray-based gene expression analysis . Plant J . 2006;46:336–348
  16. Wang HW , Trotter MW , Lagos D , et al.   Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma . Nat Genet . 2004;36:687–693
  17. Dennis G, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, et al. DAVID: Database for Annotation, Visualization, and Integrated Discovery . Genome Biol . 2003;4:P3
  18. Asahara T , Murohara T , Sullivan A , et al.   Isolation of putative progenitor endothelial cells for angiogenesis . Science . 1997;275:964–967
  19. Bompais H , Chagraoui J , Canron X , et al.   Human endothelial cells derived from circulating progenitors display specific functional properties compared with mature vessel wall endothelial cells . Blood . 2004;103:2577–2584
  20. Harris MA , Clark J , Ireland A , et al.   The Gene Ontology (GO) database and informatics resource . Nucleic Acids Res . 2004;32:D258–D261
  21. Shojaei F , Gallacher L , Bhatia M . Differential gene expression of human stem progenitor cells derived from early stages of in utero human hematopoiesis . Blood . 2004;103:2530–2540
  22. Orlic D , Anderson S , Biesecker LG , Sorrentino BP , Bodine DM . Pluripotent hematopoietic stem cells contain high levels of mRNA for c-kit, GATA-2, p45 NF-E2, and c-myb and low levels or no mRNA for c-fms and the receptors for granulocyte colony-stimulating factor and interleukins 5 and 7 . Proc Natl Acad Sci USA . 1995;92:4601–4605
  23. Ogawa M , Kizumoto M , Nishikawa S , Fujimoto T , Kodama H , Nishikawa SI . Expression of a4-integrin defines the earliest precursor of hematopoietic cell lineage diverged from endothelial cells . Blood . 1999;93:1168–1177
  24. Minegishi N , Suzuki N , Yokomizo T , et al.   Expression and domain-specific function of GATA-2 during differentiation of the hematopoietic precursor cells in midgestation mouse embryos . Blood . 2003;102:896–905
  25. Kawabata H, Germain RS, Ikezoe T, Tong X, Green EM, Gombart AF, et al. Regulation of expression of murine transferrin receptor 2 . Blood . 2001;98:1949–1954
  26. Elagib KE , Racke FK , Mogass M , Khetawat R , Delehanty LL , Goldfarb AN . RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation . Blood . 2003;101:4333–4341
  27. Takakura N , Watanabe T , Suenobu S , et al.   A role for hematopoietic stem cells in promoting angiogenesis . Cell . 2000;102:199–209
  28. Wong ET , Jenne DE , Zimmer M , Porter SD , Gilks CB . Changes in chromatin organization at the neutrophil elastase locus associated with myeloid cell differentiation . Blood . 1999;94:3730–3736
  29. Schmidt M , Fernandez de Mattos S , van der Horst A , et al.   Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D . Mol Cell Biol . 2002;22:7842–7852
  30. Leibundgut K , Schmitz NM , Hirt A . Catalytic activities of G1 cyclin-dependent kinases and phosphorylation of retinoblastoma protein in mobilized peripheral blood CD34+ hematopoietic progenitor cells . Stem Cells . 2005;23:1002–1011
  31. Forrest D , Erway LC , Ng L , Altschuler R , Curran T . Thyroid hormone receptor beta is essential for development of auditory function . Nat Genet . 1996;13:354–357
  32. White R , Leonardsson G , Rosewell I , Ann Jacobs M , Milligan S , Parker M . The nuclear receptor co-repressor nrip1 (RIP140) is essential for female fertility . Nat Med . 2000;6:1368–1374
  33. Blow JJ , Dutta A . Preventing re-replication of chromosomal DNA . Nat Rev Mol Cell Biol . 2005;6:476–486
  34. Barabasi AL , Oltvai ZN . Network biology: understanding the cell's functional organization . Nat Rev Genet . 2004;5:101–113
  35. Janes KA , Yaffe MB . Data-driven modelling of signaltransduction networks . Nat Rev Mol Cell Biol . 2006;7:820–828
  36. Mucenski ML , McLain K , Kier AB , et al.   A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis . Cell . 1991;65:677–689

PII: S1028-4559(09)60010-3

doi: 10.1016/S1028-4559(09)60010-3

Taiwanese Journal of Obstetrics and Gynecology
Volume 47, Issue 4 , Pages 422-430 , December 2008