Taiwanese Journal of Obstetrics and Gynecology
Volume 48, Issue 1 , Pages 3-8, March 2009

Placental Abnormalities and Preeclampsia in Trisomy 13 Pregnancies

  • Chih-Ping Chen

      Affiliations

    • Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
    • Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan
    • Department of Biotechnology, Asia University, Taipei, Taiwan
    • School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taipei, Taiwan
    • Institute of Clinical and Community Health Nursing, National Yang-Ming University, Taipei, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Chih-Ping Chen, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, 92, Section 2, Chung-Shan North Road, Taipei, Taiwan

Accepted 12 January 2009.

Summary 

Women who are carrying a trisomy 13 fetus are prone to have an abnormal placenta as well as to develop preeclampsia in the second and third trimesters. This article provides a comprehensive review of placental abnormalities, such as small placental volume, reduced placental vascularization, a partial molar appearance of the placenta and placental mesenchymal dysplasia, and preeclampsia associated with trisomy 13 pregnancies. The candidate preeclampsia-causing genes on chromosome 13, such as sFlt1, COL4A2 and periostin, are discussed.

Key Words:  COL4A2 , periostin , placental abnormalities , preeclampsia , pregnancy , sFlt1 , trisomy 13

No full text is available. To read the body of this article, please view the PDF online.

 

PII: S1028-4559(09)60028-0

doi:10.1016/S1028-4559(09)60028-0

Taiwanese Journal of Obstetrics and Gynecology
Volume 48, Issue 1 , Pages 3-8, March 2009

Article Tools