Taiwanese Journal of Obstetrics and Gynecology
Volume 48, Issue 1 , Pages 46-48, March 2009

Seropositivity for Listeria monocytogenes in Women with Spontaneous Abortion: A Case-Control Study in Iran

  • Mahin Jamshidi

      Affiliations

    • Corresponding Author InformationCorrespondence to: Dr Mahin Jamshidi, Infectious and Tropical Diseases Research Center, Hormozgan University of Medical Sciences, P.O. Box 13185-1678, Tehran, Iran
    • Infectious and Tropical Diseases Research Center, Hormozgan University of Medical Sciences, Banddar Abbas
    • ,
  • Abdolreza Sotoodeh Jahromi

      Affiliations

    • Department of Immunology, Jahrom University of Medical Sciences, Jahrom
    • ,
  • Parivash Davoodian

      Affiliations

    • Infectious and Tropical Diseases Research Center, Hormozgan University of Medical Sciences, Banddar Abbas
    • ,
  • Malihe Amirian

      Affiliations

    • Department of Obstetrics and Gynecology, Hormozgan University of Medical Sciences, Banddar Abbas
    • ,
  • Mehrangiz Zangeneh

      Affiliations

    • Department of Infectious Diseases, Azad University of Medical Sciences, Tehran, Iran
    • ,
  • Fatemeh Jadcareh

      Affiliations

    • Infectious and Tropical Diseases Research Center, Hormozgan University of Medical Sciences, Banddar Abbas

Accepted 11 June 2008.

Article Outline

Summary 

Objective

There are many studies supporting the role of certain asymptomatic infections such as Listeria monocytogenes (L. monocytogenes) in spontaneous abortion. In some cases, latent listeriosis may complicate the pregnancy, and serologic tests can, therefore, be used to detect the disease. This study was designed to assess the relationship between seropositivity for L. monocytogenes and spontaneous abortion.

Materials and Methods

A total of 250 women with previous spontaneous abortion and a control group of 200 women with normal full-term deliveries entered the study as case and control groups, respectively. Demographic characteristics were recorded for each subject, and serum samples were obtained from all participants. All serum samples were examined using the indirect immunofluorescence antibody test for L. monocytogenes antibody. Data was analyzed using Chi-squared and t tests.

Results

The average age of participants was 25.6 ± 7.6 years in cases and 25.3 ± 6.5 years in controls. Eighty-nine (35.6%) of the cases with abortion and 35 (17.5%) of the control group were positive for L. monocytogenes antibody (p = 0.001). No relationship was observed between the number of pregnancies and infection with L. monocytogenes (p = 0.4), or between the number of previous abortions and L. monocytogenes seropositivity (p = 0.2).

Conclusion

We suggest monitoring L. monocytogenes seroprevalence in pregnant women at high risk of threatened abortion, and further microbiological assessment of symptomatic women for detection of L. monocytogenes and insidious infection.

Key Words:  Listeria monocytogenes , pregnancy , spontaneous abortion

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References 

  1. Gellin BG , Broome CV , Bibb WF , Weaver RE , Gaventa S , Mascola L . The epidemiology of listeriosis in the United States-1986. Listeriosis Study Group . Am J Epidemiol . 1991;133:392–401
  2. Ciesielski CA , Hightower AW , Parsons SK , Broome CV . Listeriosis in the United States: 1980-1982 . Arch Intern Med . 1988;148:1416–1419
  3. Mylonakis E , Paliou M , Hohmann EL , Calderwood SB , Wing EJ . Listeriosis during pregnancy: a case series and review of 222 cases . Medicine (Baltimore) . 2002;81:260–269
  4. Teberg AJ , Yonekura ML , Salminen C , Pavlova Z . Clinical manifestations of epidemic neonatal listeriosis . Pediatr Infect Dis J . 1987;6:817–820
  5. Cossart P , Sansonetti PJ . Bacterial invasion: the paradigms of enteroinvasive pathogens . Science . 2004;304:242–248
  6. Braden CR . Listeriosis . Pediatr Infect Dis J . 2003;22:745–746
  7. Silver HM . Listeriosis during pregnancy . Obstet Gynecol Surv . 1998;53:737–740
  8. Pujol I , Vidal A , Joven J . The seroprevalence of Listeria infections without clinical sign in a population of pregnant women from the Reus area . Rev Clin Esp . 1990;187:175–177 [In Spanish]
  9. Aljicević M , Beslagić E , Zvizdić S , Hamzić S , Mahmutović S . Agglutination as screening test in routine diagnostic of listeriosis . Med Arh . 2006;60:93–95 [In Bosnian]
  10. Doganay M . Listeriosis: clinical presentation . FEMS Immunol Med Microbiol . 2003;35:173–175
  11. Benshushan A , Tsafrir A , Arbel R , Rahav G , Ariel I , Rojansky N . Listeria infection during pregnancy: a 10-year experience . Isr Med Assoc J . 2002;4:776–780
  12. Aljicević M , Beslagić E , Zvizdić S , Hamzić S , Mahmutović S . Listeria monocytogenes in women of reproductive age . Med Arh . 2005;59:297–298 [In Bosnian]
  13. Romana C , Salleras L , Sage M . Latent listeriosis may cause habitual abortion intrauterine deaths, fetal malformations: when diagnosed and treated adequately normal children will be born . Acta Microbiol Hung . 1989;36:171–172

PII: S1028-4559(09)60034-6

doi:10.1016/S1028-4559(09)60034-6

Taiwanese Journal of Obstetrics and Gynecology
Volume 48, Issue 1 , Pages 46-48, March 2009

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