Taiwanese Journal of Obstetrics and Gynecology
Volume 44, Issue 1 , Pages 57-61, March 2005

Polymorphism of the Vitamin D Receptor Gene, Bone Mineral Density, and Bone Turnover in Postmenopausal Women from Lower Silesia (Poland)

Department of Endocrinology and Diabetology, Wroclaw Medical University, Poland

Received 4 October 2004; received in revised form 20 October 2004; accepted 8 November 2004.

Article Outline

Summary 

Objective

Genetic factors are involved in determining bone mineral density (BMD) and in the pathogenesis of osteoporosis. There are relationships between various genetic polymorphisms and BMD or bone turnover. The aim of our study was to assess polymorphisms in the vitamin D receptor (VDR) gene (BsmI) in relation to BMD and bone turnover in a group of Polish postmenopausal women from the Lower Silesia region.

Materials and Methods

BMD at the lumbar spine and proximal femur, bone turnover (osteocalcin and carboxyterminal cross-linked telopeptide of type I collagen, ICTP), and restriction fragment length polymorphism (RFLP) of the VDR gene using the BsmI restriction enzyme were examined in 116 postmenopausal women.

Results

Despite the fact that we failed to detect statistically significant differences between the VDR genotypes in BMD, a trend towards higher BMD in women carrying allele b compared with wild-type subjects in our study is similar to previous reports. We also observed a higher allele b frequency in the control group (normal bone mass) compared with osteopenic/osteoporotic women (59.1% vs 40.0%). The lower activity of the resorption marker ICTP seen in allele b carriers could be involved.

Conclusion

We report an association between VDR gene polymorphism and decreased BMD in Polish postmenopausal women from the Lower Silesia region, but this requires further robust studies for confirmation.

Key Words:  MD , bone turnover , osteoporosis , VDR gene polymorphisms

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PII: S1028-4559(09)60108-X

doi:10.1016/S1028-4559(09)60108-X

Taiwanese Journal of Obstetrics and Gynecology
Volume 44, Issue 1 , Pages 57-61, March 2005

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