Taiwanese Journal of Obstetrics and Gynecology
Volume 44, Issue 2 , Pages 148-152 , June 2005

Can First-Trimester Maternal Serum Level Of Pregnancy-associated Plasma Protein-A Predict Subsequent Fetal Growth Restriction?

  • Su-Chee Chen

      Affiliations

    • Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Hsinchu, Taiwan
    • ,
  • Fa-Kung Lee

      Affiliations

    • Department of Obstetrics and Gynecology, Cathay General Hospital Hsinchu Branch, Hsinchu, Taiwan

Received 11 November 2004 ,Revised 18 November 2004 ,Accepted 18 November 2004.

References 

  1. Campbell S . The detection of intrauterine growth retardation . In:  Sharp F ,  Fraser RB ,  Milner RD editor. RCOG Study Group Proceedings: Fetal Growth . London: Royal College of Obstetricians and Gynecologists; 1989;p. 251–261
  2. Buck GM , Cookfair DL , Michalek AM , et al.   Intrauterine growth retardation and risk of sudden infant death syndrome . Am J Epidemiol . 1989;129:874–884
  3. Holst K , Andersen E , Philip J , Henningsen I . Antenatal and perinatal conditions correlated to handicap among 4-year-old children . Am J Perinatol . 1989;6:258–267
  4. Barker DJ . The fetal and infant origins of adult disease . BMJ . 1990;301:1111
  5. Ong CYT , Liao AW , Spencer K , Munim S , Nicolaides KH . First trimester maternal serum free beta-human chorionic gonadotrophin and pregnancy associated plasma protein A as predictors of pregnancy complications . Br J Obstet Gynaecol . 2000;107:1265–1270
  6. Pedersen JF , Sorensen S , Ruge S . Human placental lactogen and pregnancy-associated plasma protein A in first trimester and subsequent fetal growth . Acta Obstet Gynecol Scand . 1995;74:505–508
  7. Smith GCS , Stenhouse EJ , Crossley JA , Aitken DA , Cameron AD , Connor JM . Early pregnancy levels of pregnancy-associated plasma protein A and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth . J Clin Endocrinol Metab . 2002;87:1762–1767
  8. Johnson MR , Riddle AF , Grudzinskas JG , Sharma V , Collins WP , Nicolaides KH . Reduced circulating placental protein concentrations during the first trimester are associated with preterm labour and low birth weight . Hum Reprod . 1993;8:1942–1947
  9. Morssink LP, Kornman LH, Hallahan TW, Kloosterman MD, Beekhuis JR, de Wolf BT, et al. Maternal serum free beta-hCG and PAPP-A in the first trimester of pregnancy are not associated with subsequent fetal growth retardation or preterm delivery . Prenat Diagn . 1998;18:147–152
  10. Spencer K , Souter V , Tul N , Snijders R , Nicolaides KH . A screening program for trisomy 21 at 10–14 weeks using fetal nuchal translucency, maternal serum free beta-human chorionic gonadotropin and pregnancy-associated plasma protein-A . Ultrasound Obstet Gynecol . 1999;13:231–237
  11. Nicolaides KH , Brizot ML , Snijders RJ . Fetal nuchal translucency: ultrasound screening for fetal trisomy in the first trimester of pregnancy . Br J Obstet Gynaecol . 1994;101:782–786
  12. Lin TM , Halbert SP , Kiefer DJ , Spellacy WN , Gall S . Characterization of four human pregnancy-associated plasma proteins . Am J Obstet Gynecol . 1974;118:223–236
  13. Bischof P . Placental proteins . Contrib Gynecol Obstet . 1984;12:1–96
  14. Lawrence JB , Oxvig C , Overgaard MT , et al.   The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A . Proc Natl Acad Sci USA . 1999;96:3149–3153
  15. Rutanen EM . Insulin-like growth factors in obstetrics . Curr Opin Obstet Gynecol . 2000;12:163–168
  16. Kwik M , Morris J . Association between first trimester maternal serum pregnancy associated plasma protein-A and adverse pregnancy outcome . Aust NZ J Obstet Gynecol . 2003;43:438–442
  17. Lai TH , Chen SC , Tsai MS , Lee FK , Wei CF . First-trimester screening for Down syndrome in singleton pregnancies achieved by intrauterine insemination . J Assist Reprod Genet . 2003;20:327–331
  18. Spencer K . The influence of smoking on maternal serum PAPP-A and free beta hCG levels in the first trimester of pregnancy . Prenat Diagn . 1999;19:1065–1066
  19. Brambati B , MacIntosh MCM , Teisner B , et al.   Low maternal serum levels of pregnancy associated plasma protein A (PAPP A) in the first trimester in association with abnormal fetal karyotype . Br J Obstet Gynaecol . 1993;100:324–326
  20. Westergaard JG , Teisner B , Grudzinskas JG . Serum PAPP-A in normal pregnancy: relationship to fetal and maternal characteristics . Arch Gynecol . 1983;233:211–215
  21. Westergaard JG , Sinosich WJ , Bugge M , Madsen LT , Teisner B , Grudzinskas JG . Pregnancy-associated plasma protein A in the prediction of early pregnancy failure . Am J Obstet Gynecol . 1983;145:67–69
  22. Smith GC , Stenhouse EJ , Crossley JA , Aitken DA , Cameron AD , Connor JM . Early-pregnancy origins of low birth weight . Nature . 2002;417:916
  23. Yaron Y , Heifetz S , Ochshorn Y , Lehavi O , Urtreger AO . Decreased first trimester PAPP-A is a predictor of adverse pregnancy outcome . Prenat Diagn . 2002;22:778–782
  24. Pledger DR , Belfield A , Calder AA , Wallace AM . The predictive value of three pregnancy-associated proteins in the detection of the light-for-dates baby . Br J Obstet Gynaecol . 1984;91:870–874
  25. Bersinger NA , Groome N , Muttukrishna S . Pregnancy-associated and placental proteins in the placental tissue of normal pregnant women and patients with pre-eclampsia at term . Eur J Endocrinol . 2002;147:785–793

PII: S1028-4559(09)60127-3

doi: 10.1016/S1028-4559(09)60127-3

Taiwanese Journal of Obstetrics and Gynecology
Volume 44, Issue 2 , Pages 148-152 , June 2005

Article Tools