Taiwanese Journal of Obstetrics and Gynecology
Volume 44, Issue 3 , Pages 209-217, September 2005

Mechanisms Involved in Chemoresistance in Ovarian Cancer

  • Fu-Shing Liu

      Affiliations

    • Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr. Fu-Shing Liu, Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, 160, Section 3, Chung-Kang Road, Taichung, Taiwan

Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan

Received 11 July 2005; received in revised form 13 July 2005; accepted 14 July 2005.

Summary

Chemotherapy is a major treatment modality for ovarian cancer, but chemoresistance is a clinical problem that compromises the efficiency of treatment and finally results in treatment failure. The development of resistance to chemotherapeutic agents might be related to multiple mechanisms such as alterations in drug transport, changes in cellular proteins involved in detoxification, altered drug target, changes in DNA repair mechanisms, and increased tolerance to drug-induced DNA damage. This article is a summary of the various mechanisms that are involved in chemoresistance in ovarian cancer.

Key Words:  chemoresistance , chemotherapy , ovarian cancer

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PII: S1028-4559(09)60143-1

doi:10.1016/S1028-4559(09)60143-1

Taiwanese Journal of Obstetrics and Gynecology
Volume 44, Issue 3 , Pages 209-217, September 2005

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