Taiwanese Journal of Obstetrics and Gynecology
Volume 44, Issue 3 , Pages 218-231, September 2005

Genetic Changes in Ovarian Cancer

  • Fu-Shing Liu

      Affiliations

    • Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr. Fu-Shing Liu, Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, 160, Section 3, Chung-Kang Road, Taichung, Taiwan

Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan

Received 11 July 2005; received in revised form 13 July 2005; accepted 14 July 2005.

Summary

Ovarian cancer is among the most lethal of all malignancies in women. While chemotherapy is the preferred treatment modality, chemoresistance severely limits treatment success. Chemoresistance may be multifactorial and related to multiple mechanisms, such as alterations in drug transport, changes in cellular proteins involved in detoxification, altered drug target, changes in DNA repair mechanisms, increases in drug damage tolerance, and genetic changes. Genetic changes appear to be associated directly with the loss of chemosensitivity in ovarian cancer. In this review, we detail the possible genetic changes that occur in ovarian cancer, including activation of specific oncogenes, inactivation of tumor suppressor genes, and downregulation of metastasis suppressor genes.

Key Words:  metastasis suppressor gene , oncogene , ovarian cancer , tumor suppressor gene

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PII: S1028-4559(09)60144-3

doi:10.1016/S1028-4559(09)60144-3

Taiwanese Journal of Obstetrics and Gynecology
Volume 44, Issue 3 , Pages 218-231, September 2005

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