Taiwanese Journal of Obstetrics and Gynecology
Volume 44, Issue 4 , Pages 342-346, December 2005

Hysteroscopic Differences in the Gestational Sac in Asymptomatic Blighted Ovum and Viable Pregnancy at Early Gestation

  • Fu-Tsai Kung

      Affiliations

    • Corresponding Author InformationCorrespondence to: Dr. Fu-Tsai Kung, Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, 123, Ta Pei Road, Niao Sung Hsiang, Kaohsiung, Taiwan

Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan

Received 17 August 2005; received in revised form 29 August 2005; accepted 30 August 2005.

Article Outline

Summary 

Objective

To assess differences in the surface anatomy of the gestational sac and endometrium in cases of blighted ovum and viable pregnancies using flexible hysteroscopy.

Methods

This was an observational case-control study. Seventeen patients with asymptomatic blighted ovum at gestational ages of 8-13 weeks and 32 women with viable pregnancy at 6-12 weeks of gestation were recruited. Subjects at 8-10 weeks of gestation in both groups were matched for comparison. The gross surface anatomy of the gestational sac and the endometrium was assessed and compared between the two groups.

Results

In the viable pregnancy group, the gestational sac was either round (84.4%, 27/32) or ellipsoid and slightly creased (15.6%, 5/32). In the blighted ovum group, the sac appeared collapsed and wrinkled (58.8%, 10/17), small for gestational age (11.8%, 2/17), a combination of the two (17.6%, 3/17), or round and normal (11.8%, 2/17). In general, the sac in subjects with blighted ovum tended to have various degrees of loss in surface tension, collapse in shape, decrease in sac size, and dark blue color at the sac dome compared with the sac in viable pregnancies.

Conclusions

The anatomic alterations of the gestational sac reflect impending sac necrosis and abortion in early-stage pregnancy loss. There were no morphologic differences between the two groups in the pattern of capillary distribution on the endometrium or the implantation base.

Key Words:  blighted ovum , endometrium , gestational sac , surface anatomy

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References 

  1. Wilcox AJ , Weinberg CR , O'Connor JF , et al.   Incidence of early loss of pregnancy . N Engl J Med . 1988;319:189–194
  2. Miller JF , Williamson E , Glue J , Gordon YB , Grudzinskas JG , Sykes A . Fetal loss after implantation . Lancet . 1980;ii:554–556
  3. Brambati B , Lanzani A . A clinical look at early post-implantation pregnancy failure . Hum Reprod . 1987;2:401–405
  4. Robinson HP . The diagnosis of early pregnancy failure by sonar . Br J Obstet Gynaecol . 1975;82:849–857
  5. Nyberg DA , Laing FC , Filly RA . Threatened abortion: sonographic distinction of normal and abnormal gestation sacs . Radiology . 1986;158:397–400
  6. March CM . Hysteroscopy . J Reprod Med . 1992;37:293–312
  7. Cullen MT , Reece EA , Whetham J , Hobbins JC . Embryoscopy: description and utility of a new technique . Am J Obstet Gynecol . 1990;162:82–86
  8. Reece EA , Rotmensch S , Whetham J , Cullen M , Hobbins JC . Embryoscopy: a closer look at first trimester diagnosis and treatment . Am J Obstet Gynecol . 1992;166:775–780
  9. Quintero RA , Abuhamad A , Hobbins JC , Mahoney MJ . Transabdominal thin-gauge embryofetoscopy: a technique for early prenatal diagnosis and its use in the diagnosis of a case of Meckel-Gruber syndrome . Am J Obstet Gynecol . 1993;168:1552–1557
  10. Kung FT , Chen WJ , Chou HS , Ko SF , Chang SY . Conservative management of early endometrial adenocarcinoma with repeat curettage and hormone therapy under assistance of hysteroscopy and laparoscopy . Hum Reprod . 1997;12:1649–1653
  11. Steiner H , Gregg AR , Bogner G , Graf AH , Weiner CP , Staudach A . First trimester three-dimensional ultrasound volumetry of the gestational sac . Arch Gynecol Obstet . 1994;255:165–170
  12. Is there a place for hysteroscopy in prenatal and intrapartum diagnosis? . Lancet . 1987;1:960–961 [Editorial]
  13. Van den Eede B . I Investigation and treatment of infertile couples: ESHRE guidelines for good clinical and laboratory practice. European Society of Human Reproduction and Embryology . Hum Reprod . 1995;10:1246–1271

PII: S1028-4559(09)60168-6

doi:10.1016/S1028-4559(09)60168-6

Taiwanese Journal of Obstetrics and Gynecology
Volume 44, Issue 4 , Pages 342-346, December 2005