Taiwanese Journal of Obstetrics and Gynecology
Volume 45, Issue 2 , Pages 124-128, June 2006

Ultrasonographic Evaluation of the Change in Uterine Fibroids Induced by Treatment with a Gnrh Analog

  • Chun-Chieh Chia

      Affiliations

    • Department of Obstetrics and Gynecology, Chi Mei Hospital, Liouying, Tainan, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Chun-Chieh Chia, Department of Obstetrics and Gynecology, Chi Mei Hospital, 201 Taikang, Liouying, Tainan, Taiwan
    • ,
  • Soon-Cen Huang

      Affiliations

    • Department of Obstetrics and Gynecology, Chi Mei Hospital, Liouying, Tainan, Taiwan
    • ,
  • Shen-Shien Chen

      Affiliations

    • Department of Obstetrics and Gynecology, Tainan, Taiwan
    • ,
  • Jye-Yi Kang

      Affiliations

    • Department of Obstetrics and Gynecology, Tainan, Taiwan
    • ,
  • Jing-Chuan Lin

      Affiliations

    • Department of Obstetrics and Gynecology, Tainan, Taiwan
    • ,
  • Yuen-Shan Lin

      Affiliations

    • Department of Obstetrics and Gynecology, Tainan, Taiwan
    • ,
  • Kuo-Feng Huang

      Affiliations

    • Department of Obstetrics and Gynecology, Tainan, Taiwan
    • ,
  • Hung-Jung Lee

      Affiliations

    • Department of Obstetrics and Gynecology, Tainan, Taiwan
    • ,
  • Ching-Cheng Zheng

      Affiliations

    • Pathology, Chi Mei Medical Center, Tainan, Taiwan

Accepted 21 November 2005.

Article Outline

Summary 

Objective

To investigate the change in volume of uterine fibroids after GnRH analog (GnRHa) treatment.

Materials and Methods

Twenty-five patients who had a uterine leiomyoma were included in this study. Four of them were lost to follow-up during the study, and a myomectomy was performed on the remaining subjects. All of these patients received two doses, 4 weeks apart, each of 3.75 mg leuprorelin acetate subcutaneously (Leuplin depot, a GnRHa) before the operation. The vascularization index (VI), flow index (FI), vascularization-flow index (VFI), pulsative index (PI), resistance index (RI), vascular patterns (histogram), blood flows, and sizes (volume and largest diameter) of each fibroid were measured with power Doppler by the same technician every month before the operation. In addition, the total blood loss and time required for each operation were also recorded.

Results

Results of this study showed that the volume of the uterus and the fibroids, but not the vascularity, including VI, FI, VFI, PI and RI, decreased significantly after two doses of GnRHa treatment. In addition, blood loss during the operation decreased significantly compared to an untreated group.

Conclusion

We found that the volumes of the uterus and fibroids decreased significantly after treatment with two consecutive doses (given a month apart) of GnRHa. The 3D color Doppler including a histogram and blood flow parameters is another useful tool for fibroid evaluation.

Key Words:  GnRH analog , uterine fibroid

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References 

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PII: S1028-4559(09)60209-6

doi:10.1016/S1028-4559(09)60209-6

Taiwanese Journal of Obstetrics and Gynecology
Volume 45, Issue 2 , Pages 124-128, June 2006

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