Volume 45, Issue 3 , Pages 215-220, September 2006
Hip Circumference is an Important Predictor of Plasma C-reactive Protein Levels in Overweight and Obese Taiwanese Women
Article Outline
Summary
Objective
To investigate the relationship between serum levels of C-reactive protein (CRP) with obesity, insulin resistance and metabolic syndrome in overweight or obese Taiwanese women.
Materials and Methods
Analysis was performed on data from 59 overweight or obese women enrolled in a cross-sectional study. Pearson's correlation coefficients were determined between CRP and simple anthropometric indices, fasting insulin, homeostasis model assessment (HOMA) and serum lipid levels. Forward stepwise regression procedure was used to find a “best” subset of predictor variables for CRP.
Results
CRP was found to have significantly positive correlation with body weight, waist circumference, hip circumference, body mass index, log of fasting glucose levels, fasting insulin levels and HOMA. Forward stepwise regression procedure showed that the best predictor for CRP was hip circumference.
Conclusion
The correlation between CRP and insulin resistance or abnormal lipid levels is attributed to their strong correlations with obesity.
Key Words: body mass index , C-reactive protein , hip circumference , insulin resistance , metabolic syndrome , obesity
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References
- . Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? . Atherosclerosis . 2000;148:209–214
- . Novel clinical markers of vascular wall inflammation . Circ Res . 2001;89:763–771
- Elevated C-reactive protein: another component of the atherothrombotic profile of abdominal obesity . Arterioscler Thromb Vasc Biol . 2001;21:961–967
- . C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction . Circulation . 1998;97:2007–2011
- . Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women . Circulation . 1998;98:731–733
- . Homeostasis model assessment: insulin resistance and B-cell function from fasting plasma glucose and insulin concentrations in man . Diabetologia . 1985;28:412–419
- . Relation of C-reactive protein and coronary heart disease in the MRFIT nested case-control study. Multiple Risk Factor Intervention Trial . Am J Epidemiol . 1996;44:537–547
- . Secretory factors from human adipose tissue and their functional role . Proc Nutr Soc . 2005;64:163–169
- . Elevated C-reactive protein levels in overweight and obese adults . JAMA . 1999;282:2131–2135
- . Chronic subclinical inflammation as part of the insulin resistance syndrome. The Insulin Resistance Atherosclerosis Study (IRAS) . Circulation . 2000;102:42–47
- . C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? . Arterioscler Thromb Vasc Biol . 1999;19:972–978
- . C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus . JAMA . 2001;286:327–334
- . Low grade chronic inflammation in women with polycystic ovarian syndrome . J Clin Endocrinol Metab . 2001;86:2453–2455
- Prevalence of overweight and obesity and its associated factors: findings from National Nutrition and Health Survey in Taiwan, 1993–1996 . Prev Med . 2003;37:233–241
- . Body composition, leptin, and insulin resistance in Asian Indian Men . J Clin Endocrinol Metab . 1999;84:137–144
- . Relationship between generalized and upper body obesity to insulin resistance in Asian Indian men . J Clin Endocrinol Metab . 1999;84:137–144
- . In: Applied Linear Statistical Models . 4th edition. USA: Times Mirror Higher Education Group; 2000;p. 348–353
- . The paradox of low body mass index and high body fat percentage among Chinese, Malays and Indians in Singapore . Int J Obes Relat Metab Disord . 2000;24:1011–1017
- . Relationship between C-reactive protein and visceral adipose tissue in healthy Japanese subjects . Diabetes Obes Metab . 2004;6:249–258
- Correlates of fasting insulin levels in young adults: the CARDIA study . J Clin Epidemiol . 1991;44:571–578
- C-reactive protein concentrations are related to insulin resistance and metabolic syndrome as defined by the ATP III report . Int J Cardiol . 2004;97:101–106
- . C-reactive protein, the metabolic syndrome, and prediction of cardiovascular events in the Framingham Offspring Study . Circulation . 2004;110:380–385
PII: S1028-4559(09)60227-8
doi:10.1016/S1028-4559(09)60227-8
© 2006 Taiwan Association of Obstetric & Gynecology. Published by Elsevier Inc. All rights reserved.
Volume 45, Issue 3 , Pages 215-220, September 2006
