Taiwanese Journal of Obstetrics and Gynecology
Volume 45, Issue 4 , Pages 317-320 , December 2006

Preliminary Report on the Effect of a Lower Dose of Gonadotropin-Releasing Hormone Antagonist (Cetrorelix) on Ovarian Hyperstimulation in Lower-Weight Asian Women

  • Yung-Ling Chang

      Affiliations

    • Department of Obstetrics and Gynecology, Tung's Metro Harbor Hospital, Taiwan
    • ,
  • Yao-Yuan Hsieh

      Affiliations

    • Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan
    • ,
  • Horng-Der Tsai

      Affiliations

    • Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Horng-Der Tsai, Department of Obstetrics and Gynecology, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua 500, Taiwan

,Accepted 27 July 2006.

References 

  1. Reissmann T , Schally AV , Bouchard P , Riethmiiller H , Engel J . The LHRH antagonist cetrorelix: a review . Hum Reprod Update . 2000;6:322–331
  2. Olivennes F , Fanchin R , Bouchard P , Taieb J , Frydman R . Triggering of ovulation by a gonadotropin-releasing hormone (GnRH) agonist in patients pretreated with a GnRH antagonist . Fertil Steril . 1996;66:151–153
  3. Diedrich K, Diedrich C, Santos E, Zoll C, Al-Hasani S, Reissmann T, et al. Suppression of the endogenous luteinizing hormone surge by the gonadotropin-releasing hormone antagonist Cetrorelix during ovarian stimulation . Hum Reprod . 1994;9:788–791
  4. Felberbaum R, Reissmann T, Kupker W, Al-Hasani S, Bauer O, Schill T, et al  Hormone profiles under ovarian stimulation with human menopausal gonadotropin (hMG) and concomitant administration of the gonadotropin releasing hormone (GnRH)-antagonist Cetrorelix at different dosages . J Assist Reprod Genet . 1996;13:216–222
  5. Borm G , Mannaerts B  The European Orgalutran Study Group . Treatment with the gonadotropin-releasing hormone antagonist ganirelix in women undergoing ovarian stimulation with recombinant follicle stimulating hormone is effective, safe and convenient: results of a controlled, randomized, multicentre trial . Hum Reprod . 2000;15:1490–1498
  6. Albano C , Smitz J , Camus M , Riethmuller-Winzen H , Van Steirteghem A , Devroey P . Comparison of different doses of gonadotropin-releasing hormone antagonist Cetrorelix during controlled ovarian hyperstimulation . Fertil Steril . 1997;67:917–922
  7. Albano C , Smitz J , Tournaye H , Riethmuller-Winzen H , Van Steirteghem A , Devroey P . Luteal phase and clinical outcome after human menopausal gonadotropin/gonadotropin releasing hormone antagonist treatment for ovarian stimulation in in vitro fertilization/intracytoplasmic sperm injection cycles . Hum Reprod . 1999;14:1426–1430
  8. Hsieh YY , Tsai HD , Chang CC , Chang CC , Lo HY . Comparison of a single half-dose, long-acting form of gonadotropin-releasing hormone analog (GnRH-a) and a short-acting form of GnRH-a for pituitary suppression in a controlled ovarian hyperstimulation program . Fertil Steril . 2000;73:817–820
  9. Gianaroli L , Ferraretti AP , Feliciani E , Tabanelli C , Magli C , Fertini D . Prospective randomized study of D-Trp-6-LHRH versus buserelin in long desensitization protocols for medically assisted conception cycles . Hum Reprod . 1994;9:220–225
  10. Fujimoto VY , Monroe SE , Nelson LR , Downey D , Jaffe RB . Dose-related suppression of serum luteinizing hormone in women by a potent new gonadotropin-releasing hormone antagonist (Ganirelix) administered by intranasal spray . Fertil Steril . 1997;67:469–473
  11. Oberye JJ , Mannaerts BM , Huisman JA , Timmer CJ . Pharmacokinetic and pharmacodynamic characteristics of ganirelix (Antagon/Orgalutran). Part II. Dose-proportionality and gonadotropin suppression after multiple doses of ganirelix in healthy female volunteers . Fertil Steril . 1999;72:1006–1012
  12. Gordon K , Williams RF , Danforth DR , Hodgen GD . A novel regimen of gonadotropin-releasing hormone (GnRH) antagonist plus pulsatile GnRH: controlled restoration of gonadotropin secretion and ovulation induction . Fertil Steril . 1990;54:1140–1145
  13. The ganirelix dose-finding study group  . A double-blind, randomized, dose-finding study to assess the efficacy of the gonadotropin-releasing hormone antagonist ganirelix (Org 37462) to prevent premature luteinizing hormone surges in women undergoing ovarian stimulation with recombinant follicle stimulating hormone (Puregon) . Hum Reprod . 1998;13:3023–3031
  14. Fauser BC, Devroey P, Yen SS, Gosden R, Crowley WF, Baird DT, et al. Minimal ovarian stimulation for IVF: appraisal of potential benefits and drawbacks . Hum Reprod . 1999;14:2681–2686
  15. Itskovitz-Eldor J , Kol S , Mannaerts B , Coelingh Bennink H . First established pregnancy after controlled ovarian hyperstimulation with recombinant follicle stimulating hormone and the gonadotrophin-releasing hormone antagonist ganirelix (Org 37462) . Hum Reprod . 1998;13:294–295
  16. Felberbaum R , Diedrich K . Ovarian stimulation for in vitro fertilization/intracytoplasmic sperm injection with gonadotrophins and gonadotrophin-releasing hormone analogues: agonists and antagonists . Hum Reprod . 1999;14:207–221

PII: S1028-4559(09)60250-3

doi: 10.1016/S1028-4559(09)60250-3

Taiwanese Journal of Obstetrics and Gynecology
Volume 45, Issue 4 , Pages 317-320 , December 2006

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