Taiwanese Journal of Obstetrics and Gynecology
Volume 45, Issue 4 , Pages 321-324 , December 2006

Use of Mifepristone and Sublingual Misoprostol for Early Medical Abortion

  • Mau Lin

      Affiliations

    • Department of Obstetrics and Gynecology, Taipei, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Yiu-Tai Li, Department of Obstetrics and Gynecology, Kuo General Hospital, 22, Ming-Sheng Road, Section 2, Tainan 700, Taiwan
    • ,
  • Yiu-Tai Li

      Affiliations

    • Department of Obstetrics and Gynecology, Taipei, Taiwan
    • ,
  • Fu-Min Chen

      Affiliations

    • Department of Obstetrics and Gynecology, Chung Shan Hospital, Taipei, Taiwan
    • ,
  • Shu-Fang Wu

      Affiliations

    • Department of Nursing, Taipei, Taiwan
    • ,
  • Ching-Wan Tsai

      Affiliations

    • Department of Pharmacy, Kuo General Hospital, Tainan, Taiwan
    • ,
  • Tien-Hui Chen

      Affiliations

    • Department of Obstetrics and Gynecology, Taipei, Taiwan
    • ,
  • Tsung-Cheng Kuo

      Affiliations

    • Department of Obstetrics and Gynecology, Taipei, Taiwan

,Accepted 31 August 2006.

References 

  1. Tang OS , Schweer H , Seyberth HW , Lee SWH , Ho PC . Pharmacokinetics of different routes of administration of misoprostol . Hum Reprod . 2002;17:332–336
  2. Zieman M , Fong SK , Benowitz NL , Banskter D , Darney PD . Absorption kinetics of misoprostol with oral or vaginal administration . Obstet Gynecol . 1997;90:88–92
  3. Aronsson A , Bygdeman M , Gemzell-Danielsson K . Effect of misoprostol on uterine contractility following different routes of administration . Hum Reprod . 2004;19:81–84
  4. Peyron R , Aubeny E , Targosz V , et al.   Early termination of pregnancy with mifepristone (RU486) and the orally active prostaglandin misoprostol . N Engl J Med . 1993;328:1509–1513
  5. Kahn JG , Beaker BJ , Maclsaa L , et al.   The efficacy of medical abortion: a meta-analysis . Contraception . 2000;61:29–40
  6. El-Refaey H , Rajasekar D , Abdalla M , Calder L , Templeton A . Induction of abortion with mifepristone (RU486) and oral or vaginal misoprostol . N Engl J Med . 1995;332:983–987
  7. Lin HW , Chien TY , Jeng CJ , Chen SC , Chen HF , Hwang JL . Comparison of two doses of mifepristone in combination with misoprostol for early pregnancy termination . Taiwanese J Obstet Gynecol . 2002;41:155–161
  8. Kelly RW , Bukman A . Antiprogestagenic inhibition of uterine prostaglandin inactivation: a permissive mechanism for uterine stimulation . J Steroid Biochem Mol Biol . 1990;37:97–101
  9. Schaff EA , Eisinger SH , Stadalius LS , Franks P , Gore BZ , Poppema S . Low-dose mifepristone 200 mg and vaginal misoprostol for abortion . Contraception . 1999;59:1–6
  10. Tang OS , Ho PC . Pilot study on the use of sublingual misoprostol for medical abortion . Contraception . 2001;64:315–317
  11. Cheung W , Tang OS , Lee SWH , Ho PC . Pilot study on the use of sublingual misoprostol in termination of pregnancy up to 7 weeks of gestation . Contraception . 2003;68:47–49
  12. Tang OS , Chan CCW , Ng EHY , Lee SWH , Ho PC . A prospective, randomized, placebo-controlled trial on the use of mifepristone with sublingual or vaginal misoprostol for medical abortions of less than 9 weeks' gestation . Hum Reprod . 2003;18:2315–2318
  13. Hamoda H , Ashok PW , Dow J , Flett GMM , Templeton FA . A pilot study of mifepristone in combination with sublingual or vaginal misoprostol for medical termination of pregnancy up to 63 days' gestation . Contraception . 2003;68:335–338

PII: S1028-4559(09)60251-5

doi: 10.1016/S1028-4559(09)60251-5

Taiwanese Journal of Obstetrics and Gynecology
Volume 45, Issue 4 , Pages 321-324 , December 2006

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