Taiwanese Journal of Obstetrics and Gynecology
Volume 45, Issue 4 , Pages 325-328 , December 2006

Concurrent Use of Mifepristone and Misoprostol for Early Medical Abortion

  • Yiu-Tai Li

      Affiliations

    • Department of Obstetrics and Gynecology, Taipei, Taiwan
    • ,
  • Fu-Min Chen

      Affiliations

    • Department of Obstetrics and Gynecology, Chung Shan Hospital, Taipei, Taiwan
    • ,
  • Tien-Hui Chen

      Affiliations

    • Department of Obstetrics and Gynecology, Taipei, Taiwan
    • ,
  • Shu-Ching Li

      Affiliations

    • Department of Nursing, Kuo General Hospital, Tainan, Taiwan
    • ,
  • Min-Lung Chen

      Affiliations

    • Department of Obstetrics and Gynecology, Taipei, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Min-Lung Chen, Department of Obstetrics and Gynecology, Kuo General Hospital, 22, Ming-Sheng Road, Section 2, Tainan 700, Taiwan
    • ,
  • Tsung-Cheng Kuo

      Affiliations

    • Department of Obstetrics and Gynecology, Taipei, Taiwan

,Accepted 27 October 2006.

References 

  1. El-Refaey H , Rajasekar D , Abdalla M , Calder L , Templeton A . Induction of abortion with mifepristone (RU486) and oral or vaginal misoprostol . N Engl J Med . 1995;332:983–987
  2. Peyron R , Aubeny E , Targosz V , et al.   Early termination of pregnancy with mifepristone (RU486) and the orally active prostaglandin misoprostol . N Engl J Med . 1993;328:1509–1513
  3. Kahn JG , Beaker BJ , Maclsaa L , et al.   The efficacy of medical abortion: a meta-analysis . Contraception . 2000;61:29–40
  4. Lin HW , Chien TY , Jeng CJ , Chen SC , Chen HF , Hwang JL . Comparison of two doses of mifepristone in combination with misoprostol for early pregnancy termination . Taiwanese J Obstet Gynecol . 2002;41:155–161
  5. Swahn ML , Wang G , Aedo AR , Cekan SZ , Bygdeman M . Plasma levels of antiprogestin RU 486 following oral administration to non-pregnant and early pregnant women . Contraception . 1986;34:469–481
  6. Shi YE , Ye ZH , He CH , et al.   Pharmacokinetic study of RU 486 and its metabolite after oral administration of single doses to pregnant and non-pregnant women . Contraception . 1993;48:133–149
  7. Marions L . Mifepristone dose in the regimen for medical abortion . Contraception . 2006;74:21–25
  8. Zieman M , Fong SK , Benowitz NL , Banskter D , Darney PD . Absorption kinetics of misoprostol with oral or vaginal administration . Obstet Gynecol . 1997;90:88–92
  9. Schaff E . Evidence for shortening the time interval of prostaglandin after mifepristone for medical abortion . Contraception . 2006;74:42–44
  10. Jain JK , Dutton C , Harwood B , Meckstroth KR , Mishell DR . A prospective randomized, double-blinded, placebo-controlled trial comparing mifepristone and vaginal misoprostol to vaginal misoprostol alone for elective termination of early pregnancy . Hum Reprod . 2002;17:1477–1482
  11. Murthy AS , Creinin MD , Harwood B , Schreiber C . A pilot study of mifepristone and misoprostol administered at the same time for abortion up to 49 days gestation . Contraception . 2005;71:333–336
  12. Schreiber CA , Creinin MD , Harwood B , Murthy AS . A pilot study of mifepristone and misoprostol administered at the same time for abortion in women with gestation from 50 to 63 days . Contraception . 2005;71:447–450
  13. Kapp N , Borgatta L , Ellis SC , Stubblefield P . Simultaneous very low dose mifepristone and vaginal misoprostol for medical abortion . Contraception . 2006;73:525–527

PII: S1028-4559(09)60252-7

doi: 10.1016/S1028-4559(09)60252-7

Taiwanese Journal of Obstetrics and Gynecology
Volume 45, Issue 4 , Pages 325-328 , December 2006

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