Taiwanese Journal of Obstetrics and Gynecology
Volume 45, Issue 4 , Pages 336-339, December 2006

Synchronous Occurrence of Primary Neoplasms in the Uterus with Squamous Cell Carcinoma of the Cervix and Adenocarcinoma of the Endometrium

  • Cheng-Kuo Lin

      Affiliations

    • Department of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    • ,
  • Mu-Hsien Yu

      Affiliations

    • Department of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    • ,
  • Ta-Wei Chu

      Affiliations

    • Department of Obstetrics and Gynecology, Armed Forces Tao-Yuan General Hospital, Tao-Yuan, Taiwan
    • ,
  • Hung-Cheng Lai

      Affiliations

    • Department of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Hung-Cheng Lai, Department of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, 325, Section 2, Cheng-Kung Road, Neihu, Taipei 114, Taiwan

Accepted 29 June 2006.

Article Outline

Summary 

Objective

Synchronous primary malignant neoplasms of the uterus are uncommon. Patients with synchronous cervical and endometrial cancers are even rarer. We describe a case of cervical squamous cell carcinoma and endometrial endometrioid adenocarcinoma occurring simultaneously in a 47-year-old woman presenting with massive menstrual bleeding. The concept of synchronous primary malignancies of the genital tract is also reviewed in this report.

Case Report

A 47-year-old overtly obese female presented with menometrorrhagia of over 6 months' duration. Pelvic examination detected a large cervix but apparently normal externals. Magnetic resonance imaging revealed a mass over the cervical region and endometrial lesions in the uterine cavity. Surgical exploration disclosed a cervical tumor and erosion of the endometrium. The pathologic findings were compatible with synchronous occurrence of primary neoplasms in the uterus with squamous cell carcinoma of the cervix and adenocarcinoma of the endometrium.

Conclusion

Synchronous genital tract neoplasms are rare but cause more clinical problems than a single neoplasm. It is practical to pay more attention to the differential diagnosis of primary and metastatic tumors. The second primary cancer that occurs in an individual with endometrial cancer may offer an opportunity for early detection. The prognosis for a patient with synchronous gynecologic malignancies does not seem to be worse.

Key Words:  cervical cancer , endometrial cancer , synchronous primary malignancies

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References 

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PII: S1028-4559(09)60255-2

doi:10.1016/S1028-4559(09)60255-2

Taiwanese Journal of Obstetrics and Gynecology
Volume 45, Issue 4 , Pages 336-339, December 2006

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