Taiwanese Journal of Obstetrics and Gynecology
Volume 48, Issue 2 , Pages 113-115, June 2009

Use of 24-Hour Urinary Protein and Calcium for Prediction of Preeclampsia

  • Daya Sirohiwal
    • ,
  • Krishna Dahiya

      Affiliations

    • Corresponding Author InformationCorrespondence to: Dr Krishna Dahiya, Department of Obstetrics and Gynecology, Pandit Bhagwat Dayal Sharma, Post-Graduate Institute of Medical Sciences, 74-R, Model Town, Rohtak 124001, India
    • ,
  • Neha Khaneja

Department of Obstetrics and Gynecology, Pandit Bhagwat Dayal Sharma, Post-Graduate Institute of Medical Sciences, Rohtak, India

Accepted 19 March 2009.

Article Outline

Summary 

Objective

To assess the efficacy of 24-hour urinary protein and calcium for the prediction of preeclampsia.

Materials and Methods

Two hundred normotensive women at 20–28 weeks' gestation were enrolled in the study. All women were asked to collect a 24-hour urine sample. Urinary protein and calcium were measured and expressed as milligrams per 24 hours. Sensitivity, specificity and predictive values were calculated for each test, and cutoff values were calculated using receiver operating characteristic curves.

Results

Twenty-one of the 200 women developed preeclampsia, including eight who developed severe preeclampsia and 13 who developed mild preeclampsia. Compared with the normotensive women (n = 179), the hypertensive patients (n = 21) had significantly lower urinary calcium excretion (167.23 ± 80.63 mg vs. 277.43 ± 60.38 mg) and higher proteinuria (351.14 ± 41.58 mg vs. 296.33 ± 30.03 mg).

Conclusion

A decrease in 24-hour urinary calcium and increase in protein between 20–28 weeks' gestation are risk factors for preeclampsia.

Key Words:  24-hour urinary calcium , 24-hour urinary protein , preeclampsia

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References 

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PII: S1028-4559(09)60268-0

doi:10.1016/S1028-4559(09)60268-0

Taiwanese Journal of Obstetrics and Gynecology
Volume 48, Issue 2 , Pages 113-115, June 2009

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