Taiwanese Journal of Obstetrics and Gynecology
Volume 48, Issue 2 , Pages 142-147 , June 2009

The Effects of Calcium-Vitamin D and Metformin on Polycystic Ovary Syndrome: A Pilot Study

,Accepted 5 June 2008.

References 

  1. Laven JS , Imani B , Eijkemans MJ , Fauser BC . New approach to polycycstic ovary syndrome and other forms of anovulatory infertility . Obstet Gynecol Surv . 2002;57:755–767
  2. The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group  . Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS) . Hum Reprod . 2004;19:41–47
  3. Dunaif A , Graf M , Mandeli J , Laumas V , Dobrjansky A . Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia . J Clin Endocrinol Metab . 1987;65:499–507
  4. Robinson S , Kiddy D , Gelding SV , et al.   The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries . Clin Endocrinol (Oxf) . 1993;39:351–355
  5. Knochenhauer ES , Key TJ , Kahsar-Miller M , Waggoner W , Boots LR , Azziz R . Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study . J Clin Endocrinol Metab . 1998;83:3078–3082
  6. Asuncion M , Calvo RM , San Millan JL , Sancho J , Avila S , Escobar-Morreale HF . A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain . J Clin Endocrinol Metab . 2000;85:2434–2438
  7. Diamanti-Kandarakis E , Kouli C , Tsianateli T , Bergiele A . Therapeutic effects of metformin on insulin resistance and hyperandrogenism in polycystic ovary syndrome . Eur J Endocrinol . 1998;138:269–274
  8. Nestler JE , Jakubowicz DJ , Evans WS , Pasquali R . Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome . N Engl J Med . 1998;338:1876–1880
  9. Ledger WL . Non-reproductive consequences of polycystic ovary syndrome . Curr Obstet Gynaecol . 2003;13:350–354
  10. De Felici M , Dolci S , Siracusa G . An increase of intracellular free Ca2+ is essential for spontaneous meiotic resumption by mouse oocytes . J Exp Zool . 1991;260:401–405
  11. Steinhardt RA , Epel D , Carroll EJ , Yanagimachi R . Is calcium ionophore a universal activator for unfertilised eggs? . Nature . 1974;252:41–43
  12. Homa ST , Carroll J , Swann K . The role of calcium in mammalian oocyte maturation and egg activation . Hum Reprod . 1993;8:1274–1281
  13. Thys-Jacobs S , Donovan D , Papadopoulos A , Sarrel P , Bilezikian JP . Vitamin D and calcium dysregulation in the polycystic ovarian syndrome . Steroids . 1999;64:430–435
  14. Stumpf WE . Vitamin D sites and mechanisms of action: a histochemical perspective . Histochem Cell Biol . 1995;104:417–427
  15. Barnes R , Rosenfield RL . The polycystic ovary syndrome: pathogenesis and treatment . Ann Int Med . 1989;110:386–399
  16. Kaufman ML , Homa ST . Defining a role for calcium in the resumption and progression of meiosis in the pig oocyte . J Exp Zool . 1993;265:69–76
  17. Ullah G , Jung P , Machaca K . Modeling Ca2+ signaling differentiation during oocyte maturation . Cell Calcium . 2007;42:556–564
  18. Lee JH , Yoon SY , Bae IH . Studies on Ca2+ -channel distribution in maturation arrested mouse oocyte . Mol Reprod Dev . 2004;69:174–185
  19. Kitai H , Santulli R , Wright KH , Wallach EE . Examination of the role of calcium in ovulation in the in vitro perfused rabbit ovary with use of ethyleneglycol-bis(beta-aminoethyl ether)-n, n′-tetraacetic acid and verapamil . Am J Obstet Gynecol . 1985;152:705–708
  20. The George Mateljan Foundation  . Vitamin D for polycystic ovary syndrome . Available at: http://www.whfoods.com/genpage.php?tname=news&dbid=45#article [Date accessed: 15 September 2003]
  21. Hahn S , Haselhorst U , Tan S , et al.   Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome . Exp Clin Endocrinol Diabetes . 2006;114:577–583
  22. Velazquez E , Acosta A , Mendoza SG . Menstrual cyclicity after metformin therapy in polycystic ovary syndrome . Obstet Gynecol . 1997;90:392–395

PII: S1028-4559(09)60275-8

doi: 10.1016/S1028-4559(09)60275-8

Taiwanese Journal of Obstetrics and Gynecology
Volume 48, Issue 2 , Pages 142-147 , June 2009