Volume 48, Issue 3 , Pages 225-231, September 2009
The Effects of Absent or Reversed End-diastolic Umbilical Artery Doppler Flow Velocity
Article Outline
Summary
Abnormal umbilical artery flow with absent or reversed end-diastolic velocity (AREDV) during pregnancy is a strong indication of placental insufficiency. When AREDV occurs prenatally, a close follow-up or expeditious delivery should be contemplated. AREDV in the umbilical artery is associated with intraventricular hemorrhage, bronchopulmonary dysplasia, and perinatal mortality. It may be associated with respiratory distress syndrome, necrotizing enterocolitis, and long-term neurodevelopmental impairment. Available data suggest that women with high-risk pregnancies, such as preeclampsia, gestational hypertension and intrauterine growth restriction, should be evaluated with umbilical artery Doppler velocimetry to reduce the possibility of perinatal mortality and morbidity.
Key Words: absent or reversed end-diastolic velocity , fetal growth retardation , perinatal mortality , placental insufficiency , preeclampsia , pregnancy complications
No full text is available. To read the body of this article, please view the PDF online.
References
- . Umbilical artery velocity waveforms and intrauterine growth retardation . Am J Obstet Gynecol . 1985;151:502–506
- The clinical significance of Doppler umbilical artery velocimetry in the small for gestational age fetus . Am J Obstet Gynecol . 1987;156:1223–1226
- . Fetal umbilical artery velocity waveforms and subsequent neonatal outcome . Br J Obstet Gynaecol . 1991;98:378–384
- . The significance of increasing umbilical artery systolic-diastolic ratios in third-trimester pregnancy . Obstet Gynecol . 1992;80:684–687
- . Assessment of fetal compromise by Doppler ultrasound investigation of the fetal circulation: arterial, intracardiac, and venous blood flow velocity studies . Circulation . 1995;91:129–138
- . Relationship between arterial and venous Doppler and perinatal outcome in fetal growth restriction . Ultrasound Obstet Gynecol . 2000;16:407–413
- Temporal sequence of abnormal Doppler changes in the peripheral and central circulatory systems of the severely growth-restricted fetus . Ultrasound Obstet Gynecol . 2002;19:140–146
- . Fetal umbilical artery flow velocity waveforms and placental resistance: pathological correlation . Br J Obstet Gynaecol . 1985;92:31–38
- . Pathology and clinical implications of abnormal umbilical artery Doppler waveforms . Ultrasound Obstet Gynecol . 1997;9:271–286
- . Umbilical and uteroplacental blood flow velocity waveforms in pregnancies with fetal growth retardation . Eur J Obstet Gynecol Reprod Biol . 1988;27:187–196
- . Impact of reverse end-diastolic flow velocity in umbilical artery on pregnancy outcome after the 28th gestational week . Acta Obstet Gynecol Scand . 1998;77:527–531
- . Doppler umbilical velocimetry in the prediction of adverse outcome in pregnancies at risk for intrauterine growth retardation . Obstet Gynecol . 1988;71:742–746
- . Is intrauterine growth retardation with normal umbilical artery blood flow a benign condition? . BMJ . 1990;300:1044–1045
- . Fetal umbilical artery velocity waveforms and subsequent neonatal outcome . Br J Obstet Gynaecol . 1991;98:378–384
- . Is an abnormal Doppler umbilical artery waveform ratio a risk factor for poor perinatal outcome in the non-small for gestational age fetus? . Am J Perinatol . 1993;10:245–249
- . Prognostic role of umbilical artery Doppler velocimetry in growth-restricted fetuses . J Matern Fetal Neonatal Med . 2002;11:199–203
- Outcome of 60 neonates who had ARED flow prenatally compared with a matched control group of appropriate-for-gestational age preterm neonates . Ultrasound Obstet Gynecol . 2005;25:566–572
- . Doppler ultrasonography in high-risk pregnancies: systematic review with meta-analysis . Am J Obstet Gynecol . 1995;172:1379–1387
- . Intraventricular hemorrhage and periventricular leukomalacia in preterm infants . Obstet Gynecol . 2004;104:225–231
- . Evidence of redistribution of cardiac output in asymmetrical growth retardation . Br J Obstet Gynaecol . 1989;96:697–704
- . Intraventricular hemorrhage in the premature infant—current concepts, part I . Ann Neurol . 1989;25:3–11
- . Fetal platelet consumption: a feature of placental insufficiency . Obstet Gynecol . 1991;77:616–621
- . Growth deficient fetuses with absent or reversed umbilical artery end-diastolic flow are metabolically compromised . Early Hum Dev . 1995;41:1–9
- . Neonatal nucleated red blood cell and lymphocyte counts in fetal brain injury . Obstet Gynecol . 1998;91:485–489
- . Placental lesion multiplicity: risk factor for IUGR and neonatal cranial ultrasound abnormalities . Early Hum Dev . 2001;62:1–10
- . Value of absent or retrograde end-diastolic flow in fetal aorta and umbilical artery as a predictor of perinatal outcome in pregnancy-induced hypertension . Acta Paediatr . 1993;82:919–924
- . Is it time to reassess the risk for the growth-retarded fetus with normal Doppler velocimetry of the umbilical artery? . Am J Obstet Gynecol . 1994;170:1734–1741
- . An abnormal umbilical artery waveform: a strong and independent predictor of adverse perinatal outcome in patients with preeclampsia . Am J Obstet Gynecol . 1994;171:713–721
- . Clinical significance of absent or reversed end diastolic velocity waveforms in umbilical artery . Lancet . 1994;344:1664–1668
- . Antenatal prediction of intraventricular hemorrhage in fetal growth restriction: what is the role of Doppler? . Ultrasound Obstet Gynecol . 2002;19:334–339
- . Effect of absent end diastolic flow velocity in the fetal umbilical artery on subsequent outcome . Arch Dis Child Fetal Neonatal Ed . 1997;76:35–38
- . Prognostic value of umbilical artery Doppler studies in unselected preterm deliveries . Obstet Gynecol . 2005;105:613–620
- Neonatal neurosono-graphic correlates of cerebral palsy in preterm infants . Pediatrics . 1986;78:88–95
- . Prediction of cerebral palsy in very low birthweight infants: prospective ultrasound study . Lancet . 1987;2:593–596
- . The association of fetal and newborn metabolic acidosis with severe periventricular leukomalacia in the preterm newborn . Am J Obstet Gynecol . 1990;162:977–981
- . Inflammatory mediators and bronchopulmonary dysplasia . Arch Dis Child Fetal Neonatal Ed . 1995;73:1F–3F
- Do clinical markers of barotraumas and oxygen toxicity explain interhospital variation in rates of chronic lung disease? . Pediatrics . 2000;105:1194–1201
- . Prevention of bronchopulmonary dysplasia . Curr Opin Pediatr . 2001;13:124–129
- . Neurodevelopment and predictors of outcomes of children with birth weights of less than 1000 g: 1992–1995 . Arch Pediatr Adolesc Med . 2000;154:725–731
- Extremely low birthweight neonates with protracted ventilation: mortality and 18-month neurodevelopmental outcomes . J Pediatr . 2005;146:798–804
- . Relationship between abnormal fetal testing and adverse perinatal outcomes in intrauterine growth restriction . Am J Obstet Gynecol . 2007;196:48–51
- . Respiratory outcome in preterm small for gestational age fetuses with or without abnormal umbilical artery Doppler and/or maternal hypertension . J Matern Fetal Neonatal Med . 2007;20:613–621
- Acute necrotizing enterocolitis in infancy: a review of 64 cases . Pediatrics . 1975;55:376–387
- . Necrotizing enterocolitis: a review of pathogenetic mechanisms and implications for prevention . Pediatr Pathol . 1993;13:357–369
- . Risk factors for necrotising enterocolitis: the influence of gestational age . Arch Dis Child . 1992;67:432–435
- . Necrotising enterocolitis: perinatal approach to prevention, early diagnosis and management . Semin Neonatol . 1997;2:291–296
- . Morbidity and mortality among very-low-birth weight neonates with intrauterine growth restriction . Am J Obstet Gynecol . 2000;182:198–206
- . Feeding growth restricted preterm infants with abnormal antenatal Doppler results . Arch Dis Child Fetal Neonatal Ed . 2005;90:F359–F363
- Predictors of necrotizing enterocolitis in preterm growth-restricted neonates . Am J Obstet Gynecol . 2008;198:638.e1–638.e5
- . Absent end-diastolic velocity in umbilical artery: risk of neonatal morbidity and brain damage . Am J Obstet Gynecol . 1994;170:796–801
- . Long term predictive value of Doppler studies in high risk fetuses . Br J Obstet Gynaecol . 1992;99:575–578
- . Infants of women with severe early pre-eclampsia: the effect of absent end-diastolic umbilical artery Doppler flow velocities on neurodevelopmental outcome . Acta Paediatr . 2000;89:566–570
- . Blood flow velocity waveforms of the middle cerebral artery and abnormal neurological evaluations in live-born fetuses with absent or reverse enddiastolic flow velocities of the umbilical arteries . Eur J Obstet Gynecol Reprod Biol . 1992;45:93–100
- . Neonatal and neurodevelopmental outcome in infants born before 30 weeks of gestation with absent or reversed enddiastolic flow velocities in the umbilical artery . Eur J Pediatr . 2001;160:128–134
- . Outcome at school age following antenatal detection of absent or reversed end diastolic flow velocity in the umbilical artery . Arch Dis Child Fetal Neonatal Ed . 2002;86:108–114
- . Absent or reverse end-diastolic flow in the umbilical artery: intellectual development at school age . Eur J Obstet Gynecol Reprod Biol . 2004;114:23–28
- . Undernutrition and the developing brain: the use of animal models to elucidate the human problem . Psychiatr Neurol Neurochir . 1971;74:433–442
- . Vulnerability of developing brain, II: effects of early nutritional deprivation on reflex ontogeny and development of behavior in the rat . Brain Res . 1971;28:85–95
- . Structure of the fetal sheep brain in experimental growth retardation . J Dev Physiol . 1988;10:211–225
- Early alteration of structural and functional brain development in premature infants born with intrauterine growth restriction . Pediatr Res . 2004;56:132–138
- A classification of hypertension in pregnancy based on Doppler velocimetry . Am J Obstet Gynecol . 1987;157:680–685
- . The role of the spiral arteries in the pathogenesis of pre-eclampsia . Obstet Gynecol Annu . 1972;1:177–191
- . Maternal perinatal outcome of conservative management of severe preeclampsia in midtrimester . Am J Obstet Gynecol . 1985;152:32–37
- . Determinants of perinatal outcome in pregnancy-induced hypertension with absence of umbilical artery end-diastolic frequencies . Am J Obstet Gynecol . 1991;164:1084–1089
- . Infant wellbeing at 2 years of age in the Growth Restriction Intervention Trial (GRIT): multicentred randomised controlled trial . Lancet . 2004;364:513–520
- . Clinical use of Doppler in pregnancy: information from six randomized trials . Fetal Diagn Ther . 1993;8:247–255
- . Randomized controlled trials of umbilical artery Doppler velocimetry: how many are too many? . Ultrasound Obstet Gynecol . 1995;6:377–379
- . Doppler ultrasound for fetal assessment in high risk pregnancies . Cochrane Database Syst Rev . 2000;(2): CD000073.
- . Umbilical artery Doppler velocimetry in unselected and low risk pregnancies: a review of randomised controlled trials . Br J Obstet Gynaecol . 1997;104:425–430
- . The use of umbilical artery Doppler ultrasonography in modern obstetrics . Curr Opin Obstet Gynecol . 1997;9:370–374
- . Routine Doppler ultrasound in pregnancy . Cochrane Database Syst Rev . 2000;(2): CD001450.
PII: S1028-4559(09)60294-1
doi:10.1016/S1028-4559(09)60294-1
© 2009 Taiwan Association of Obstetric & Gynecology. Published by Elsevier Inc. All rights reserved.
Volume 48, Issue 3 , Pages 225-231, September 2009
