Taiwanese Journal of Obstetrics and Gynecology
Volume 48, Issue 3 , Pages 273-277 , September 2009

Dual Action of Memantine in Alzheimer Disease: A Hypothesis

  • Tzong-Yuan Wu

      Affiliations

    • Department of Bioscience Technology, Chung Yuan Christian University, Chungli, Taiwan
    • R&D Center of Membrane Technology, Chung Yuan Christian University, Chungli, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Tzong-Yuan Wu, Department of Bioscience Technology, Chung Yuan Christian University, 200, Chung Pei Road, Chungli 32023, Taiwan
  • ,
  • Chih-Ping Chen

      Affiliations

    • Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
    • Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan

,Accepted 20 July 2009.

References 

  1. Roberson ED , Mucke L . 100 years and counting: prospects for defeating Alzheimer's disease . Science . 2006;314:781–784
  2. Goedert M , Spillantini MG . A century of Alzheimer's disease . Science . 2006;314:777–781
  3. Kidd M . Paired helical filaments in electron microscopy of Alzheimer's disease . Nature . 1963;197:192–193
  4. Terry RD , Gonatas NK , Weiss M . Ultrastructural studies in Alzheimer's presenile dementia . Am J Pathol . 1964;44:269–297
  5. Doraiswamy PM , Xiong GL . Pharmacological strategies for the prevention of Alzheimer's disease . Expert Opin Pharmacother . 2006;7:1–10
  6. Farlow MR . Utilizing combination therapy in the treatment of Alzheimer's disease . Expert Rev Neurother . 2004;4:799–808
  7. Boothby LA , Doering PL . Vitamin C and vitamin E for Alzheimer's disease . Ann Pharmacother . 2005;39:2073–2080
  8. Miller ER , Pastor-Barriuso R , Dalal D , Riemersma RA , Appel LJ , Guallar E . Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality . Ann Intern Med . 2005;142:37–46
  9. Nunomura A , Castellani RJ , Zhu X , Moreira PI , Perry G , Smith MA . Involvement of oxidative stress in Alzheimer disease . J Neuropathol Exp Neurol . 2006;65:631–641
  10. Lleó A , Greenberg SM , Growdon JH . Current pharmacotherapy for Alzheimer's disease . Annu Rev Med . 2006;57:513–533
  11. Mattson MP . Pathways towards and away from Alzheimer's disease . Nature . 2004;430:631–639
  12. Chen YJ , Zeng SJ , Hsu JT , et al.   Amantadine as a regulator of internal ribosome entry site . Acta Pharmacol Sin . 2008;29:1327–1333
  13. Kozak M . Context effects and inefficient initiation at non-AUG codons in eucaryotic cell-free translation systems . Mol Cell Biol . 1989;9:5073–5080
  14. Pelletier J , Sonenberg N . Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA . Nature . 1988;334:320–325
  15. Jang SK , Krausslich HG , Nicklin MJH , Duke GM , Palmenberg AC , Wimmer E . A segment of the 5′ nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation . J Virol . 1988;62:2636–2643
  16. Martinez-Salas E . The impact of RNA structure on picornavirus IRES activity . Trends Microbiol . 2008;16:230–237
  17. Hellen CU , Sarnow P . Internal ribosome entry sites in eukaryotic mRNA molecules . Genes Dev . 2001;15:1593–1612
  18. Woolaway KE , Lazaridis K , Belsham GJ , Carter MJ , Roberts LO . The 5′ untranslated region of Rhopalosiphum padi virus contains an internal ribosome entry site which functions efficiently in mammalian, plant, and insect translation systems . J Virol . 2001;75:10244–10249
  19. Chen YJ , Chen WS , Wu TY . Development of a bi-cistronic baculovirus expression vector by the Rhopalosiphum padi virus 5′ internal ribosome entry site . Biochem Biophys Res Commun . 2005;335:616–623
  20. Wu TY , Wu CY , Chen YJ , Chen CY , Wang CH . The 5′ untranslated region of Perina nuda virus (PnV) possesses a strong internal translation activity in baculovirus-infected insect cells . FEBS Lett . 2007;581:3120–3126
  21. Sachs AB . Cell cycle-dependent translation initiation: IRES elements prevail . Cell . 2000;101:243–245
  22. Holcik M , Lefebvre C , Yeh C , Chow T , Korneluk RG . A new internal-ribosome-entry-site motif potentiates XIAP-mediated cytoprotection . Nat Cell Biol . 1999;1:190–192
  23. Martinez-Salas E , Ramos R , Lafuente E , Lopez de Quinto S . Functional interactions in internal translation initiation directed by viral and cellular IRES elements . J Gen Virol . 2001;82:973–984
  24. Pinkstaff JK , Chappell SA , Mauro VP , Edelman GM , Krushel LA . Internal initiation of translation of five dendritically localized neuronal mRNAs . Proc Natl Acad Sci USA . 2001;98:2770–2775
  25. Steward O , Levy WB . Preferential localization of polyribosomes under the base of dendritic spines in granule cells of the dentate gyrus . J Neurosci . 1982;2:284–291
  26. Gardiol A , Racca C , Triller A . Dendritic and postsynaptic protein synthetic machinery . J Neurosci . 1999;19:168–179
  27. Tiedge H , Brosius J . Translational machinery in dendrites of hippocampal neurons in culture . J Neurosci . 1996;16:7171–7181
  28. Kuhl D , Skehel P . Dendritic localization of mRNAs . Curr Opin Neurobiol . 1998;8:600–606
  29. Steward O . mRNA localization in neurons: a multipurpose mechanism? . Neuron . 1997;18:9–12
  30. Steward O , Falk PM , Torre ER . Ultrastructural basis for gene expression at the synapse: synapse-associated polyribosome complexes . J Neurocytol . 1996;25:717–734
  31. Audigier S , Guiramand J , Prado-Lourenco L , et al.   Potent activation of FGF-2 IRES-dependent mechanism of translation during brain development . RNA . 2008;14:1852–1864
  32. Beaudoin ME , Poirel VJ , Krushel LA . Regulating amyloid precursor protein synthesis through an internal ribosomal entry site . Nucleic Acids Res . 2008;36:6835–6847
  33. Veo BL , Krushel LA . Translation initiation of the human tau mRNA through an internal ribosomal entry site . J Alzheimers Dis . 2009;16:271–275
  34. Qin X , Sarnow P . Preferential translation of internal ribosome entry site-containing mRNAs during the mitotic cycle in mammalian cells . J Biol Chem . 2004;279:13721–13728
  35. van Marum RJ . Update on the use of memantine in Alzheimer's disease . Neuropsychiatr Dis Treat . 2009;5:237–247
  36. Aoki FY , Sitar DS . Clinical pharmacokinetics of amantadine hydrochloride . Clin Pharmacokinet . 1988;14:35–51

PII: S1028-4559(09)60303-X

doi: 10.1016/S1028-4559(09)60303-X

Taiwanese Journal of Obstetrics and Gynecology
Volume 48, Issue 3 , Pages 273-277 , September 2009