Taiwanese Journal of Obstetrics and Gynecology
Volume 48, Issue 4 , Pages 350-355 , December 2009

Effect of Estrogen on the Activity and Growth of Human Osteoclasts In Vitro

  • Fang-Ping Chen

      Affiliations

    • Department of Obstetrics and Gynecology, National Taiwan Ocean University, Keelung, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Fang-Ping Chen, Department Of Obstetrics and Gynecology, Keelung Chang Gung Memorial Hospital, 222, Mai-Chin Road, Keelung, Taiwan
    • ,
  • Kun-Chuang Wang

      Affiliations

    • Department Orthopedic Surgery, Keelung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, National Taiwan Ocean University, Keelung, Taiwan
    • ,
  • Jing-Duan Huang

      Affiliations

    • Institute of Marine Biology, National Taiwan Ocean University, Keelung, Taiwan

,Accepted 8 December 2008.

References 

  1. Hughes DE , Dai A , Tiffee JC , Li HH , Mundy GR , Boyce BF . Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-β . Nat Med . 1996;2:1132–1136
  2. Mano H , Yuasa T , Kameda T , et al.   Mammalian mature osteoclasts as estrogen target cells . Biochem Biophys Res Commun . 1996;223:637–642
  3. Tobias JH , Chambers TJ . The effect of sex hormones on bone resorption by rat osteoclasts . Acta Endocrinol (Copenh) . 1991;124:121–127
  4. Horowitz MC . Cytokines and estrogen in bone: anti-osteoporotic effects . Science . 1993;260:626–627
  5. Manolagas SC , Jilka RL . Bone marrow, cytokines, and bone remodeling: emerging insights into the pathophysiology of osteoporosis . N Engl J Med . 1995;332:305–311
  6. Pacifici R . Estrogen, cytokines, and pathogenesis of post-menopausal osteoporosis . J Bone Miner Res . 1996;8:1043–1051
  7. Turner RT , Riggs BL , Spelsberg TC . Skeletal effects of estrogen . Endocr Rev . 1994;15:275–300
  8. Roodman GD . Cell biology of the osteoclast . Exp Hematol . 1999;27:1229–1241
  9. Kimble RB , Bain SD , Pacifici R . The functional block of TNF but not of IL-6 prevents bone loss in ovariectomized mice . J Bone Miner Res . 1997;12:935–941
  10. Cosman F , Lindsay R . Selective estrogen receptor modulators: clinical spectrum . Endocr Rev . 1999;20:418–434
  11. Chen FP , Lee N , Wang KC , Soong YK , Huan KE . Effect of estrogen and 1α,25(OH)2-vitamin D3 on the activity and growth of human primary osteoblast-like cells in vitro . Fertil Steril . 2002;77:1038–1043
  12. Stanley ER , Guilbert LJ , Tushinski RJ , Bartelmez SH . CSF-1–a mononuclear phagocyte lineage-specific hemopoietic growth factor . J Cell Biochem . 1983;21:151–159
  13. Takeshita S , Kaji K , Kudo A . Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts . J Bone Miner Res . 2000;15:1477–1488
  14. Kawamoto S , Ejiri S , Nagaoka E , Ozawa H . Effects of oestrogen deficiency on osteoclastogenesis in the rat periodontium . Arch Oral Biol . 2002;47:67–73
  15. Ramalho AC, Couttet P, Baudoin C, Morieux C, Graulet AM, de Vernejoul MC, et al. Estradiol and raloxifene decrease the formation of multinucleate cells in human bone marrow cultures . Eur Cytokine Netw . 2002;13:39–45
  16. Shevde NK , Bendixen AC , Dienger KM , Pike JW . Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repression . Proc Natl Acad Sci U S A . 2000;14:7829–7834
  17. Srivastava S , Toraldo G , Weitzmann MN , Cenci S , Ross FP , Pacifici R . Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-κB ligand (RANKL)-induced JNK activation . J Biol Chem . 2001;276:8836–8840
  18. Sarma U , Edwards M , Motoyoshi K , Flanagan AM . Inhibition of bone resorption by 17β-estradiol in human bone marrow cultures . J Cell Physiol . 1998;175:99–108

PII: S1028-4559(09)60323-5

doi: 10.1016/S1028-4559(09)60323-5

Taiwanese Journal of Obstetrics and Gynecology
Volume 48, Issue 4 , Pages 350-355 , December 2009

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