Taiwanese Journal of Obstetrics and Gynecology
Volume 48, Issue 4 , Pages 375-379 , December 2009

Comparison of the Efficacy of Two Vaginal Progesterone Formulations, Crinone 8% Gel and Utrogestan Capsules, Used for Luteal Support in Blastocyst Stage Embryo Transfers

  • Li-Jung Wang

      Affiliations

    • Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital–Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    • ,
  • Fu-Jen Huang

      Affiliations

    • Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital–Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    • ,
  • Fu-Tsai Kung

      Affiliations

    • Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital–Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    • ,
  • Pin-Yao Lin

      Affiliations

    • Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital–Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    • ,
  • Shiuh Young Chang

      Affiliations

    • Department of Obstetrics and Gynecology, Sheng An Hospital, Kaohsiung, Taiwan
    • ,
  • Kuo-Chung Lan

      Affiliations

    • Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital–Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    • Corresponding Author InformationCorrespondence to: Dr Kuo-Chung Lan, Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital–Kaohsiung Medical Center, Chang Gung University College of Medicine, 123, Ta-Pei Road, Niaosung Hsiang, Kaohsiung, Taiwan

,Accepted 20 June 2009.

References 

  1. Fatemi HM , Popovic-Todorovic B , Papanikolaou E , Donoso P , Devroey P . An update of luteal phase support in stimulated IVF cycles . Hum Reprod Update . 2007;13:581–590
  2. Bergquist C , Nillius SJ , Wide L . Human gonadotropin therapy, II: serum estradiol and progesterone patterns during nonconceptual cycles . Fertil Steril . 1983;39:766–771
  3. Howles CM , Macnamee MC , Edwards RG . Follicular development and early luteal function of conception and nonconceptional cycles after human in-vitro fertilization: endocrine correlates . Hum Reprod . 1987;2:17–21
  4. Smitz J , Devroey P , Camus M , et al.   The luteal phase and early pregnancy after combined GnRH-agonist/HMG treatment for superovulation in IVF or GIFT . Hum Reprod . 1988;3:585–590
  5. Forman R , Fries N , Testart J , Belaisch-Allart J , Hazout A , Frydman R . Evidence for an adverse effect of elevated serum estradiol concentrations on embryo implantation . Fertil Steril . 1988;49:118–122
  6. Tavaniotou A , Albano C , Smitz J , Devroey P . Comparison of LH concentrations in the early and mid-luteal phase in IVF cycles after treatment with HMG alone or in association with the GnRH antagonist Cetrorelix . Hum Reprod . 2001;16:663–667
  7. Belaisch-Allart J , De Mouzon J , Lapousterle C , Mayer M . The effect of HCG supplementation after combined GnRH agonist/HMG treatment in an IVF programme . Hum Reprod . 1990;5:163–166
  8. Claman P , Domingo M , Leader A . Luteal phase support in in-vitro fertilization using gonadotrophin releasing hormone analogue before ovarian stimulation: a prospective randomized study of human chorionic gonadotrophin versus intramuscular progesterone . Hum Reprod . 1992;7:487–489
  9. Smith EM , Anthony FW , Gadd SC , Masson GM . Trial of support treatment with human chorionic gonadotrophin in the luteal phase after treatment with buserelin and human menopausal gonadotrophin in women taking part in an in vitro fertilisation programme . BMJ . 1989;298:1483–1486
  10. Penzias AS . Luteal phase support . Fertil Steril . 2002;77:318–323
  11. Tavaniotou A , Smitz J , Bourgain C , Devroey P . Comparison between different routes of progesterone administration as luteal phase support in infertility treatments . Hum Reprod Update . 2000;6:139–148
  12. Blake DA , Farquhar CM , Johnson N , Proctor M . Cleavage stage versus blastocyst stage embryo transfer in assisted conception . Cochrane Database Syst Rev . 2007;(4): CD002118.
  13. Lan KC , Huang FJ , Lin YC , Kung FT , Chang SY . Zona-free versus laser zona-assisted hatching blastocyst transfer: a comparison of outcomes . Fertil Steril . 2009;91:1959–1962
  14. Lan KC , Huang FJ , Lin YC , et al.   The predictive value of using a combined Z-score and day 3 embryo morphology score in the assessment of embryo survival on day 5 . Hum Reprod . 2003;18:1299–1306
  15. Ou YC, Lan KC, Huang FJ, Kung FT, Lan TH, Chang SY. Comparison of in vitro fertilization versus intracytoplasmic sperm injection in extremely low oocyte retrieval cycles. Fertil Steril doi:10.1016/j.fertnstert.2008.09.039.
  16. De Ziegler D , Fanchin R , Massonneau M , Bergeron C , Frydman R , Bouchard P . Hormonal control of endometrial receptivity: the egg donation model and controlled ovarian hyperstimulation . Ann N Y Acad Sci . 1994;734:209–220
  17. Kolb BA , Paulson RJ . The luteal phase of cycles utilizing controlled ovarian hyperstimulation and the possible impact of this hyperstimulation on embryo implantation . Am J Obstet Gynecol . 1997;176:1262–1267 discussion 1267–9.
  18. Toner JP , Hassiakos DK , Muasher SJ , Hsiu JG , Jones HW . Endometrial receptivities after leuprolide suppression and gonadotropin stimulation: histology, steroid receptor concentrations, and implantation rates . Ann N Y Acad Sci . 1991;622:220–229
  19. Abramowicz JS , Archer DF . Uterine endometrial peristalsis– a transvaginal ultrasound study . Fertil Steril . 1990;54:451–454
  20. Daya S , Gunby JL . WITHDRAWN: luteal phase support in assisted reproduction cycles . Cochrane Database Syst Rev . 2008;(3): CD004830.
  21. Kleinstein J , Luteal Phase Study Group  . Efficacy and tolerability of vaginal progesterone capsules (Utrogest 200) compared with progesterone gel (Crinone 8%) for luteal phase support during assisted reproduction . Fertil Steril . 2005;83:1641–1649
  22. Geber S , Moreira AC , de Paula SO , Sampaio M . Comparison between two forms of vaginally administered progesterone for luteal phase support in assisted reproduction cycles . Reprod Biomed Online . 2007;14:155–158
  23. Simunic V , Tomic V , Tomic J , Nizic D . Comparative study of the efficacy and tolerability of two vaginal progesterone formulations, Crinone 8% gel and Utrogestan capsules, used for luteal support . Fertil Steril . 2007;87:83–87

PII: S1028-4559(09)60326-0

doi: 10.1016/S1028-4559(09)60326-0

Taiwanese Journal of Obstetrics and Gynecology
Volume 48, Issue 4 , Pages 375-379 , December 2009

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